http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26609
Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis (Articolo in rivista)
- Type
- Label
- Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
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- Pannone G.; De Maria S.; Zamparese R.; Metafora S.; Serpico R.; Morelli F.; Rubins C.; Farina E.; Carteni M.; Staibano S.; De Rosa G.; Lo Muzio L. and Bufo P. (literal)
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- http://www.spandidos-publications.com/ijo/30/6/1349 (literal)
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- ISI Web of Science (WOS) (literal)
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- Department of Surgical Sciences, University of Foggia, Foggia;
Department of Biochemistry, Second University of Naples, Naples;
Institute of Genetics and Biophysics 'A. Buzzati Traverso', CNR Naples, Naples;
Department of Oral Pathology,Second University of Naples, Naples; Institute of Pathology, University of Ancona, Ancona;
Department of Biomorphological and Functional Sciences, Section of Surgical Pathology, University of Naples Federico II, Naples, Italy (literal)
- Titolo
- Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis (literal)
- Abstract
- Human telomerase reverse transcriptase (hTERT) gene expression in resected specimens of oral squamous cell carcinoma (OSCC) and their surrounding tissue, either apparently normal or clearly histologically dysplastic, was evaluated by both real-time RT-PCR and immunohisto-chemical protein analyses. The expression level of hTERT in oral dysplasia and in OSCC was markedly higher than in normal tissues. The correlation between hTERT expression in OSCC and clinico-pathological parameters or survival of OSCC patients was statistically analyzed. Our study demonstrates that there is no significant relationship between hTERT expression and classical clinico-pathological parameters. Interestingly, survival analysis showed both overexpressing cases and lower survival rate in the early stage of OSCC (p=0.03 for immunohistochemistry; p=0.04 for RT real-time PCR). The histological location of hTERT in these tumors has been discussed in the context of the cancer stem cell theory. (literal)
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