The active translation of MHCII mRNA during dendritic cells maturation supplies new molecules to the cell surface pool. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The active translation of MHCII mRNA during dendritic cells maturation supplies new molecules to the cell surface pool. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Malanga D, Barba P, Harris PE, Maffei A, Del Pozzo G (2007)
  The active translation of MHCII mRNA during dendritic cells maturation supplies new molecules to the cell surface pool.
  in Cellular immunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Malanga D, Barba P, Harris PE, Maffei A, Del Pozzo G (literal)

Pagina inizio

• 75 (literal)

Pagina fine

• 80 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 246 (literal)

Rivista

• Cellular immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Pubblicazione (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IGB \"ABT\" (literal)

Titolo

• The active translation of MHCII mRNA during dendritic cells maturation supplies new molecules to the cell surface pool. (literal)

Abstract

• The transition of human dendritic cells (DCs) from the immature to the mature phenotype is characterized by an increased density of MHC class II (MHCII) molecules on the plasma membrane, a key requirement of their competence as professional antigen presenting cells (APCs). MHCII molecules on the cell surface derive from newly synthesized as well as from preexisting proteins. So far, all the studies done on DCs during maturation, to establish the relative contribution of newly synthesized MHCII molecules to the cell surface pool did not produced a clear, unified scenario. We report that, in human DCs stimulated ex vivo with LPS, the changes in the RNA accumulation specific for at least two MHCII genes (HLA-DRA and HLA-DQA1) due to transcriptional upregulation, is associated with the active translation at high rate of these transcripts. Our finding reveals that, across the 24h of the maturation process in human DCs, newly synthesized MHCII proteins are supplied to the APCs cell surface pool. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR

• GIOVANNA DEL POZZO (Unità di personale interno)
• PASQUALE BARBA (Persona)
• ANTONELLA MAFFEI (Persona)

Insieme di parole chiave

• Parole chiave di "The active translation of MHCII mRNA during dendritic cells maturation supplies new molecules to the cell surface pool." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR di

• GIOVANNA DEL POZZO (Unità di personale interno)
• PASQUALE BARBA (Persona)
• ANTONELLA MAFFEI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cellular immunology (Rivista)

Insieme di parole chiave di

• Parole chiave di "The active translation of MHCII mRNA during dendritic cells maturation supplies new molecules to the cell surface pool." (Insieme di parole chiave)