Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Leo D, di Porzio U, Racagni G, Riva MA, Fumagalli F, Perrone-Capano C (2007)
  Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function
  in Experimental neurology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Leo D, di Porzio U, Racagni G, Riva MA, Fumagalli F, Perrone-Capano C (literal)

Pagina inizio

• 472 (literal)

Pagina fine

• 480 (literal)

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• 203 (literal)

Rivista

• Experimental neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Pubblicazione (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Genetics and Biophysics “A. Buzzati Traverso”, CNR, Via Pietro Castellino, 111, 80131-Naples, Italy bCenter of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Via Balzaretti 9, 20133-Milan, Italy cI.R.C.C.S. San Giovanni di Dio-Fatebenefratelli, Brescia, Italy dUniversity of Naples “Federico II”, Department of Biological Sciences, Naples, Italy (literal)

Titolo

• Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function (literal)

Abstract

• Chronic cocaine use leads to pronounced alterations in neuronal functions in brain circuits associated with reward. In the present study, we examined in the rat midbrain the effects of acute, subchronic (5 days) and chronic cocaine treatments (14 days) on the gene expression of transcription factors involved in the development and maintenance of dopaminergic neurons. We show that chronic, but not acute or subchronic, cocaine administration downregulates Nurr1 and Pitx3 transcripts whereas En1 transcripts are upregulated. Conversely, Lmx1b and En2 transcripts are not affected by the drug treatment, indicating that the modulation of the midbrain transcription factors analyzed is highly selective. Interestingly, modification of the gene expression for these transcription factors persists in midbrain as long as two weeks after the last drug administration, suggesting that it may account for some of the enduring alterations in midbrain dopaminergic circuits associated with chronic cocaine use. (literal)

Prodotto di

• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• CARLA PERRONE CAPANO (Unità di personale esterno)
• UMBERTO DI PORZIO (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR di

• UMBERTO DI PORZIO (Persona)
• CARLA PERRONE CAPANO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental neurology (Rivista)