http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26555
Ochratoxin A and zearalenone: a comparative study on genotoxic effects and cell death induced in bovine lymphocytes (Articolo in rivista)
- Type
- Label
- Ochratoxin A and zearalenone: a comparative study on genotoxic effects and cell death induced in bovine lymphocytes (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.mrgentox.2003.09.009 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Lioi M.B.; Santoro A.; Barbieri R.; Salzano S.; Ursini M.V. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Scienze delle Produzioni Animali, Università della Basilicata, Via N. Sauro 85-85100 Potenza, Italy
Istituto di Endocrinologia e Oncologia Sperimentale, CNR, Napoli, Italy
Istituto di Genetica e Biofisica, \"A. Buzzati Traverso\", CNR, Napoli, Italy (literal)
- Titolo
- Ochratoxin A and zearalenone: a comparative study on genotoxic effects and cell death induced in bovine lymphocytes (literal)
- Abstract
- Ochratoxin A (OTA) and zearalenone (ZEA), two naturally occurring contaminants of animal feed, have been implicated in several mycotoxicoses in farm livestock but there is little information on their genotoxicity and toxicity in these species. Therefore, we investigated on the cytogenetic and cytotoxic effects of both OTA and ZEA in in vitro cultures of bovine lymphocytes. We determined chromosome aberrations (CAs) and sister chromatid exchanges (SCEs) as well as the mitotic index (MI) and cell viability following OTA and ZEA treatment. This report is the first to provide evidence of a statistically significant increase of structural CAs and of SCEs/cell associated with a reduction of the MI in all OTA- and ZEA-treated bovine lymphocyte cultures and a clear reproducible reducing effect of OTA on cell viability mediated by enhanced apoptosis. OTA-induced programmed cell death was not limited to bovine lymphocytes, as comparable data were demonstrated in the human leukemic T-cell line Jurkat (literal)
- Prodotto di
- Autore CNR
- Insieme di parole chiave
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
- Insieme di parole chiave di