http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26551

Corneal avascularity is due to soluble VEGF receptor-1 (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Corneal avascularity is due to soluble VEGF receptor-1 (Articolo in rivista) (literal)

Anno

2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1038/nature05249 (literal)

Alternative label

Ambati B.K.; Nozaki M.; Singh N.; Takeda A.; Jani P.D.; Suthar T.; Albuquerque R.J.; Richter E.; Sakurai E.; Newcomb M.T.; Kleinman M.E.; Caldwell R.B.; Lin Q.; Ogura Y.; Orecchia A.; Samuelson D.A.; Agnew D.W.; St Leger J.; Green W.R.; Mahasreshti P.J.; Curiel D.T.; Kwan D.; Marsh H.; Ikeda S.; Leiper L.J.; Collinson J.M.; Bogdanovich S.; Khurana T.S.; Shibuya M.; Baldwin M.E.; Ferrara N.; Gerber H.P.; De Falco S.; Witta J.; Baffi J.Z.; Raisler B.J.; Ambati J. (2006)
Corneal avascularity is due to soluble VEGF receptor-1
in Nature (Lond.); Nature Publishing Group, New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Ambati B.K.; Nozaki M.; Singh N.; Takeda A.; Jani P.D.; Suthar T.; Albuquerque R.J.; Richter E.; Sakurai E.; Newcomb M.T.; Kleinman M.E.; Caldwell R.B.; Lin Q.; Ogura Y.; Orecchia A.; Samuelson D.A.; Agnew D.W.; St Leger J.; Green W.R.; Mahasreshti P.J.; Curiel D.T.; Kwan D.; Marsh H.; Ikeda S.; Leiper L.J.; Collinson J.M.; Bogdanovich S.; Khurana T.S.; Shibuya M.; Baldwin M.E.; Ferrara N.; Gerber H.P.; De Falco S.; Witta J.; Baffi J.Z.; Raisler B.J.; Ambati J. (literal)

Pagina inizio

993 (literal)

Pagina fine

997 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.nature.com/nature/journal/v443/n7114/full/nature05249.html (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

443 (literal)

Rivista

Nature (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

7114 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Med Coll Georgia, Dept Ophthalmol and Dept Cell Biol, Augusta, GA 30907 USA; Augusta Vet Affairs Med Ctr, Augusta, GA 30907 USA Univ Kentucky, Dept Ophthalmol & Visual Sci, Dept Internal Med, and Dept Physiol, Lexington, KY 40506 USA; Nagoya City Univ, Sch Med, Dept Ophthalmol, Nagoya, Aichi 4678601, Japan; Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA; IRCCS, IDI, Mol & Cell Biol Lab, I-00167 Rome, Italy; Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA; Univ Calif Davis, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA; Sea World, Dept Pathol, San Diego, CA 92109 USA; Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA; 1Johns Hopkins Med Inst, Wilmer Inst, Eye Pathol Lab, Baltimore, MD 21205 USA; Univ Alabama, Gene Therapy Ctr, Div Human Gene Therapy, Birmingham, AL 35294 USA; James Cook Univ N Queensland, Sch Trop Environm Studies & Geog, Townsville, Qld 4811, Australia; Univ Wisconsin, Dept Med Genet, Madison, WI 53706 USA; Univ Aberdeen, Sch Med Sci, Aberdeen AB25 2ZD, Scotland; Univ Penn, Sch Med, Penn Muscle Inst, Philadelphia, PA 19104 USA; Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA; Univ Tokyo, Inst Med Sci, Tokyo 1088639, Japan; Dept Mol Oncol, San Francisco, CA 94080 USA; CNR, Inst Genet & Biophys, I-80131 Naples, Italy. (literal)

Titolo

Corneal avascularity is due to soluble VEGF receptor-1 (literal)

Abstract

Corneal avascularity-the absence of blood vessels in the cornea-is required for optical clarity and optimal vision, and has led to the cornea being widely used for validating pro- and anti-angiogenic therapeutic strategies for many disorders. But the molecular underpinnings of the avascular phenotype have until now remained obscure and are all the more remarkable given the presence in the cornea of vascular endothelial growth factor (VEGF)-A, a potent stimulator of angiogenesis, and the proximity of the cornea to vascularized tissues. Here we show that the cornea expresses soluble VEGF receptor-1 (sVEGFR-1; also known as sflt-1) and that suppression of this endogenous VEGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice. The spontaneously vascularized corneas of corn1 and Pax6+/- mice and Pax6+/- patients with aniridia are deficient in sflt-1, and recombinant sflt-1 administration restores corneal avascularity in corn1 and Pax6+/- mice. Manatees, the only known creatures uniformly to have vascularized corneas, do not express sflt-1, whereas the avascular corneas of dugongs, also members of the order Sirenia, elephants, the closest extant terrestrial phylogenetic relatives of manatees, and other marine mammals (dolphins and whales) contain sflt-1, indicating that it has a crucial, evolutionarily conserved role. The recognition that sflt-1 is essential for preserving the avascular ambit of the cornea can rationally guide its use as a platform for angiogenic modulators, supports its use in treating neovascular diseases, and might provide insight into the immunological privilege of the cornea. (literal)

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