http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26550
Activation of urokinase receptor by a novel interaction between the connecting peptide region of urokinase and alpha v beta 5 integrin (Articolo in rivista)
- Type
- Label
- Activation of urokinase receptor by a novel interaction between the connecting peptide region of urokinase and alpha v beta 5 integrin (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1242/jcs.03067 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Franco P.; Vocca I.; Carriero M.V.; Alfano D.; Cito L.; Longanesi-Cattani I.; Grieco P.; Ossowski L.; Stoppelli M.P. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council, Via P. Castellino 111, 80131 Naples, Italy
Department of Experimental Oncology, National Cancer Institute of Naples, Via M. Semmola, Naples, Italy
Department of Pharmaceutical and Toxicological Chemistry, University Federico II, Naples, Italy
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA (literal)
- Titolo
- Activation of urokinase receptor by a novel interaction between the connecting peptide region of urokinase and alpha v beta 5 integrin (literal)
- Abstract
- The serine protease urokinase (uPA) binds to the urokinase receptor (uPAR) through its growth-factor domain (GFD, residues 1-49), affecting cell migration, adhesion and growth. Here, we show that uPA can promote cytoskeletal rearrangements and directional cell migration in a GFDindependent manner, through a new and specific interaction between an internal uPA domain coined 'connecting peptide' (residues 132-158) and cell-surface integrin \"v!5. Remarkably, a peptide corresponding to this region (CPp, residues 135-158) retains the ability to bind to \"v!5, eliciting cytoskeletal rearrangements and directing cell migration at a concentration as low as 1-10 pM. These effects are lost in cells not expressing uPAR, indicating that the uPAR is required for CPp-dependent signaling. Furthermore, the CPp-\"v!5-integrin interaction enhances F-actin-enriched protrusions and cell migration induced by the well-established interaction between the uPAR-binding peptide (GFDp, residues 12-32) of uPA and uPAR. These results provide new insight into the function of uPA, which - through individual domains - can engage two different surface receptors (uPAR and \"v!5 integrin), thus initiating and potentiating intracellular signaling and migration. (literal)
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