Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma (Articolo in rivista)

Type
Label
  • Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/bm400849n (literal)
Alternative label
  • Antonino Mazzaglia+ Maria Luisa Bondì, Angela Scala, Francesca Zito, Giovanna Barbieri, Francesco Crea, Giuseppina Vianelli, Placido G. Mineo, Tiziana Fiore, Claudia Pellerito, Lorenzo Pellerito, and Maria Assunta Costa. (2013)
    Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma
    in Biomacromolecules
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Antonino Mazzaglia+ Maria Luisa Bondì, Angela Scala, Francesca Zito, Giovanna Barbieri, Francesco Crea, Giuseppina Vianelli, Placido G. Mineo, Tiziana Fiore, Claudia Pellerito, Lorenzo Pellerito, and Maria Assunta Costa. (literal)
Pagina inizio
  • 3820 (literal)
Pagina fine
  • 3829 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 14 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR - Istituto per lo Studio dei Materiali Nanostrutturati, UOS Palermo, c/o Dip. Scienze Chimiche dell'Università di Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy; ?CNR - Istituto per lo Studio dei Materiali Nanostrutturati, UOS Palermo, Via Ugo La Malfa 153, 90146 Palermo, Italy; ?CNR - Istituto di Biomedicina e Immunologia Molecolare 'Alberto Monroy', Via Ugo La Malfa 153, 90146 Palermo, Italy. ? Dipartimento di Scienze Chimiche, Università di Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy ; ++ Dipartimento di Scienze Chimiche, Università di Catania, and I.N.S.T.M. UdR of Catania, Viale A. Doria 6, 95125 Catania, Italy and CNR-IPCF Istituto per i Processi Chimico Fisici, Viale Ferdinando Stagno D'Alcontres, 37, 98158 - Messina, Italy; §Dipartimento di Fisica e 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 Chimica Università degli Studi di Palermo, Viale delle Scienze, Parco d'Orleans, 90128 Palermo; §§ CIRCMSB - Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, Via Celso Ulpiani, 27 - 70125 Bari, Italy. ?CNR - Istituto di Biofisica, UOS Palermo, Via Ugo La Malfa 153, 90146 Palermo, Italy. (literal)
Titolo
  • Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma (literal)
Abstract
  • Amphiphilic cyclodextrin (ACyD) provides watersoluble and adaptable nanovectors by modulating the balance between the hydrophobic and hydrophilic chains at both CyD sides. This work aimed to design nanoassemblies based on nonionic and hydrophilic ACyD (SC6OH) for the delivery of a poor-water-soluble organotin(IV)-porphyrin derivative [(Bu3Sn)4TPPS] to melanoma cancer cells. To characterize the porphyrin derivatives under simulated physiological conditions, a speciation was performed using complementary techniques. In aqueous solution (<=20 ?M), (Bu3Sn)4TPPS primarily exists as a monomer (2 in Figure 1), as suggested by the low static anisotropy (? ? 0.02) with a negligible formation of porphyrin supramolecular aggregates. MALDI-TOF spectra indicate the presence of moieties (i.e., [(Bu3Sn)3TPPS]-) that are derivatives of the monomeric species. Spectrofluorimetry coupled with potentiometric measurements primarily assesses the presence of the hydrolytic [(Bu3Sn)4TPPS (OH)4]4- species under physiological conditions. Nanoassemblies of (Bu3Sn)4TPPS/SC6OH were prepared by dispersion of organic films in PBS at pH 7.4 and were investigated using a combination of spectroscopic and morphological techniques. The UV-vis and emission fluorescence spectra of the (Bu3Sn)4TPPS/SC6OH reveal shifts in the peculiar bands of the organotin(IV)-porphyrin derivative due to its interaction with the ACyD supramolecular assemblies in aqueous solution. The mean size was within the range of 100-120 nm. The ?-potential was negative (-16 mV) for the (Bu3Sn)4TPPS/SC6OH nanoassemblies, with an entrapment efficiency of approximately 67%. The intracellular delivery, cytotoxicity, nuclear morphology and cell growth kinetics were evaluated via fluorescence microscopy on A375 human melanoma cells. The delivery of (Bu3Sn)4TPPS by ACyD with respect to free (Bu3Sn)4TPPS increases the internalization efficiency and cytotoxicity to induce apoptotic cell death and, at lower concentrations, changes the cellular morphology and prevents cell proliferation. (literal)
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