Effect of interferon alpha on MHC class II gene expression in ex vivo human islet tissue (Articolo in rivista)

Type
Label
  • Effect of interferon alpha on MHC class II gene expression in ex vivo human islet tissue (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbadis.2006.05.001 (literal)
Alternative label
  • Harris, Paul E.; Malanga, Donatella; Liu, Zhuoro; Hardy, Mark A.; Souza, Fabiola; Del Pozzo, Giovanna; Winchester, Robert J.; Maffei, Antonella (2006)
    Effect of interferon alpha on MHC class II gene expression in ex vivo human islet tissue
    in Biochimica et biophysica acta. Molecular basis of disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Harris, Paul E.; Malanga, Donatella; Liu, Zhuoro; Hardy, Mark A.; Souza, Fabiola; Del Pozzo, Giovanna; Winchester, Robert J.; Maffei, Antonella (literal)
Pagina inizio
  • 627 (literal)
Pagina fine
  • 635 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1762 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WoS) (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Consiglio Nazionale delle Ricerche (CNR); Columbia University; Columbia University; Columbia University (literal)
Titolo
  • Effect of interferon alpha on MHC class II gene expression in ex vivo human islet tissue (literal)
Abstract
  • Type 1 diabetes (T1D) is caused by autoimmune destruction of the insulin-producing beta-cells of the islets of Langerhans. One still open question is where naive islet-reactive T cells encounter antigens and become stimulated. In this report we have re-examined the expression of MHC class II (MHCII) genes in human islets to further explore the possibility that non-professional antigen presenting cells (APCs) within islets contribute to autoimmunity. Since development of T1D has been linked to viral infections, we also studied ex-vivo MHCII expression in response to interferon-alpha (IFN alpha) in islet tissue and in different APCs. The findings are: first, MHCII genes expression in human islets is linked with the expression of the class II transactivator isoform transcribed from the promoter IV, similar to that described in non-professional APCs. Second, there is IFN alpha-mediated lineage-specific regulation of MHCII genes expression, seen as a decrease in the accumulation of MHCII transcripts in pancreatic islets opposite to an increase in dendritic cells and beta-lymphoblastoid cell lines. Third, there is allele-specific regulation of the HLA-DQA1 gene by IFN alpha in islet tissue. These findings may begin to explain the molecular events that create favorable conditions for organ-specific autoimmunity and explain the incomplete penetrance of T1D susceptibility alleles. (c) 2006 Elsevier B.V. All rights reserved. (literal)
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