http://www.cnr.it/ontology/cnr/individuo/prodotto/ID265155
Analysis of the spatial patterns of consanguinity and its association with late childbearing in Sardinia using advanced GIS methods (Rapporti tecnici/preprint/working paper)
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- Analysis of the spatial patterns of consanguinity and its association with late childbearing in Sardinia using advanced GIS methods (Rapporti tecnici/preprint/working paper) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
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- P. Astolfi; A. Lisa; S. Tentoni; G. Zei (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
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- Department of Biology and Biotechnologies, University of Pavia;
Istituto di Genetica Molecolare IGM-CNR, Pavia, Italy;
Istituto di Matematica Applicata e Tecnologie Informatiche IMATI-CNR, Pavia, Italy. (literal)
- Titolo
- Analysis of the spatial patterns of consanguinity and its association with late childbearing in Sardinia using advanced GIS methods (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#tipoDiCuratela
- Abstract
- The current Western tendency to postpone childbearing is widely studied for its onerous personal
and socio-economic cost in reproductive outcome and progeny health. Such behaviour is
particularly alarming in those populations, like the Italian one, characterized by extremely low
fertility rates. We show how advanced GIS techniques can be used to identify regions where
mothers succeed in late reproduction, and to investigate the role of possible biological
determinants. Through spatial analysis we explored consanguinity in Sardinia and its association
with late childbearing, using 1930-1969 data regarding consanguineous marriages and fertility of
contemporaneous women. We identified a Central-Eastern zone where, despite the expected
negative impact of inbreeding on fertility, such positive association exists and does not
significantly change the incidence of highly fertile mothers, by that suggesting that genetic
determinants, enhanced in homozygous association, can affect late fertility. Since this area
includes the Ogliastra region, widely studied for its genetic homogeneity, and largely overlaps
the well known 'Blue Zone' of extreme longevity, its population qualifies for further deeper
investigations on possible common biological, genetic and environmental determinants (literal)
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