Core-shell poly-methylmethacrylate nanoparticles as effective carriers of electrostatically loaded anionic porphyrin (Articolo in rivista)

Type
Label
  • Core-shell poly-methylmethacrylate nanoparticles as effective carriers of electrostatically loaded anionic porphyrin (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/c2pp25393c (literal)
Alternative label
  • Varchi, Greta and Benfenati, Valentina and Pistone, Assunta and Ballestri, Marco and Sotgiu, Giovanna and Guerrini, Andrea and Dambruoso, Paolo and Liscio, Andrea and Ventura, Barbara (2013)
    Core-shell poly-methylmethacrylate nanoparticles as effective carriers of electrostatically loaded anionic porphyrin
    in Photochemical & photobiological sciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Varchi, Greta and Benfenati, Valentina and Pistone, Assunta and Ballestri, Marco and Sotgiu, Giovanna and Guerrini, Andrea and Dambruoso, Paolo and Liscio, Andrea and Ventura, Barbara (literal)
Pagina inizio
  • 760 (literal)
Pagina fine
  • 769 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Varchi, G (Reprint Author), Italian Natl Res Council, Inst Organ Synth & Photoreact, Via P Gobetti 101, I-40129 Bologna, Italy. Varchi, Greta; Benfenati, Valentina; Pistone, Assunta; Ballestri, Marco; Sotgiu, Giovanna; Guerrini, Andrea; Dambruoso, Paolo; Liscio, Andrea; Ventura, Barbara, Italian Natl Res Council, Inst Organ Synth & Photoreact, I-40129 Bologna, Italy. (literal)
Titolo
  • Core-shell poly-methylmethacrylate nanoparticles as effective carriers of electrostatically loaded anionic porphyrin (literal)
Abstract
  • Among the medical applications of nanoparticles, their usage as photosensitizer (PS) carriers for photodynamic therapy (PDT) has attracted increasing attention. In the present study we explored the morphological and photophysical properties of core-shell PMMA nanoparticles (PMMA-NPs) electrostatically post-loaded with the synthetic, water soluble 5,10,15,20-tetrakis(4-sulphonatophenyl)-porphyrin (TPPS4). pH response and singlet oxygen analyses of differently loaded samples proved the high capability of the PMMA-NPs to shield the PS from the environment, while retaining the PS singlet oxygen production capability. Preliminary in vitro imaging and phototoxicity experiments on HepG2 cells demonstrated the efficacy of the system to trigger photoinduced cell death in the culture. (literal)
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