The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2. (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/1567-1364.12094 (literal)

Alternative label

• Guaragnella N, Palermo V, Galli A, Moro L, Mazzoni C, Giannattasio S. (2014)
  The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2.
  in FEMS yeast research (Online); John Wiley & Sons Inc., Hoboken (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Guaragnella N, Palermo V, Galli A, Moro L, Mazzoni C, Giannattasio S. (literal)

Pagina inizio

• 2 (literal)

Pagina fine

• 16 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• FEMS yeast research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR - Istituto di Biomembrane e Bioenergetica, Bari CNR - Istituto di fisiologia Clinica, Pisa Dipartimento di Biiologia e Biotecnologie \"C. Darwin\", Università \"Sapienza\", Roma (literal)

Titolo

• The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2. (literal)

Abstract

• When the glucose supply is high, despite the presence of oxygen Saccharomyces cerevisiae uses fermentation as its main metabolic pathway and switches to oxidative metabolism only when this carbon source is limited. There are similarities between glucose-induced repression of oxidative metabolism of yeast and metabolic reprogramming of tumor cells. The glucose-induced repression of oxidative metabolism is regulated by oncogene homologues in yeast, such as Ras and Sch9p, the yeast homologue of Akt. Yeast also undergoes an apoptosis-like programmed cell death process sharing several features with mammalian apoptosis, including oxidative stress and a major role played by mitochondria. Evasion of apoptosis and sustained proliferative signalling are hallmarks of cancer. This, together with the possibility of heterologous expression of human genes in yeast, has allowed new insights to be obtained into the function of mammalian oncogenes/oncosuppressors. Here we elaborate on the similarities between tumor and yeast cells underpinning the use of this model organism in cancer research. We also review the achievements obtained through heterologous expression in yeast of p53, BRCA1 and BRCA2 which are among the best known cancer susceptibility genes, with the aim of understanding their role in tumorigenesis. Yeast cell-based functional assays for cancer genetic testing will also be dealt with. This article is protected by copyright. All rights reserved. (literal)

Editore

• John Wiley & Sons Inc. (Editore)

Prodotto di

• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• ALVARO GALLI (Unità di personale interno)
• LOREDANA MORO (Unità di personale interno)
• SERGIO GIANNATTASIO (Persona)
• NICOLETTA GUARAGNELLA (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR di

• LOREDANA MORO (Unità di personale interno)
• SERGIO GIANNATTASIO (Persona)
• ALVARO GALLI (Unità di personale interno)
• NICOLETTA GUARAGNELLA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEMS yeast research (Rivista)

Editore di

• John Wiley & Sons Inc. (Editore)