Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery (Articolo in rivista)

Type
Label
  • Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Francesca Di Rosa; Angela Santoni (2002)
    Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery
    in European Journal of Immunology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Francesca Di Rosa; Angela Santoni (literal)
Pagina inizio
  • 1873 (literal)
Pagina fine
  • 1880 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 32 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Il lavoro descrive le caratteristiche funzionali e fenotipiche dei linfociti T CD8 localizzati nel midollo osseo in paragone a quelli della milza e dei linfonodi periferici (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Santoni A= Laboratory of Pathophysiology, Regina Elena Cancer Institute, Rome, Italy and Department of Experimental Medicine and Pathology, University of Rome \"La Sapienza\", Rome, Italy (literal)
Titolo
  • Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery (literal)
Abstract
  • In addition to its well-established use for hematopoiesis reconstitution, bone marrow is considered with increasing interest as a possible source of mature cells for adoptive therapies, in particular for the immuno-therapy of cancer. Nevertheless, the peculiarities of bone marrow T cells in comparison with those in lymphoid periphery are still largely unknown. In this report, we show for the first time that bone marrow CD8 T cells are in a different activation state than those in peripheral lymphoid organs. Firstly, we observed that mouse bone marrow contains a significantly higher percentage of blasts within the CD8 T cells than either spleen or lymph nodes, yet such enrichment is not due to recent antigenic stimulation. Secondly, when we challenged bone marrow CD8 T cells from immunized mice with their antigen in vitro, they displayed a faster response than those from the spleen. Thus, we suggest that the bone marrow could be a preferential source of CD8 T cells for adoptive therapies in those cases in which highly active effectors are required. (literal)
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