Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1101/gr.197001 (literal)

Alternative label

• Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, Archidiacono N, Graves JA, Forabosco A, D'Urso M. (2001)
  Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution.
  in Genome research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, Archidiacono N, Graves JA, Forabosco A, D'Urso M. (literal)

Pagina inizio

• 2095 (literal)

Pagina fine

• 2100 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Gianfrancesco F corresponding author (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Genome research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Int Inst Genet & Biophys, I-80125 Naples, Italy (literal)

Titolo

• Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (literal)

Abstract

• The human pseudoautosomal region 1 (PAR1) is essential for meiotic pairing and recombination, and its deletion causes male sterility. Comparative studies of human and mouse pseudoautosomal genes are valuable in charting the evolution of this interesting region, but have been limited by the paucity of genes conserved between the two species. We have cloned a novel human PAR1 gene, DHRSXY, encoding an oxidoreductase of the short-chain dehydrogenase/reductase family, and isolated a mouse ortholog Dhrsxy. We also searched for mouse homologs of recently reported PGPL and TRAMP genes that flank it within PAR1. We recovered a highly conserved mouse ortholog of PGPL by cross-hybridization, but found no mouse homolog of TRAMP. Like Csf2ra and Il3ra, both mouse homologs are autosomal; Pgpl on chromosome 5, and Dhrsxy subtelomeric on chromosome 4. TRAMP, like the human genes within or near PAR1, is probably very divergent or absent in the mouse genome. We interpret the rapid divergence and loss of pseudoautosomal genes in terms of a model of selection for the concentration of repetitive recombinogenic sequences that predispose to high recombination and translocation. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Variabilità del genoma ed alterazioni genetiche nell'uomo e loro impatto biologico - (SV.P13.004.001) (Modulo)

Autore CNR

• FERNANDO GIANFRANCESCO (Persona)
• MICHELE D'URSO (Unità di personale interno)
• TERESA ESPOSITO (Unità di personale interno)

Incoming links:

Autore CNR di

• MICHELE D'URSO (Unità di personale interno)
• FERNANDO GIANFRANCESCO (Persona)
• TERESA ESPOSITO (Unità di personale interno)

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Variabilità del genoma ed alterazioni genetiche nell'uomo e loro impatto biologico - (SV.P13.004.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genome research (Rivista)