http://www.cnr.it/ontology/cnr/individuo/prodotto/ID264685
Beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid (Articolo in rivista)
- Type
- Label
- Beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Alternative label
E. Bramanti, L. Fulgentini, R. Bizzarri, F. Lenci, A. Sgarbossa, (2013)
Beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid
in The journal of physical chemistry. B
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- E. Bramanti, L. Fulgentini, R. Bizzarri, F. Lenci, A. Sgarbossa, (literal)
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Scopus (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- ICCOM Pisa
IBF Pisa
INO Pisa (literal)
- Titolo
- Beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid (literal)
- Abstract
- There is an emerging interest in small natural molecules for their potential
therapeutic use in neurodegenerative disorders like Alzheimer's Disease (AD). Ferulic acid (FA),
an antioxidant phenolic compound present in fruit and vegetables, has been proposed as an
inhibitor of beta amyloid (A?) pathological aggregation. Using fluorescence and Fourier
transform infrared spectroscopy, electrophoresis techniques, chromatographic analysis and
confocal microscopy we investigated the effects of FA on the early stages of A? fibrillogenesis
in vitro. Our results show that FA interacts promptly with A? monomers/oligomers, interfering
since the beginning with its self-assembly and finally forming amorphous aggregates more prone
to destabilization. These findings highlight the molecular basis underlying FA antiamyloidogenic
activity in AD. (literal)
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