Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case-control study. (Articolo in rivista)

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  • Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case-control study. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ijid.2013.07.006 (literal)
Alternative label
  • Chiaretti A, Pulitanò S, Conti G, Barone G, Buonsenso D, Manni L, Capozzi D, Ria F, Riccardi R. (2013)
    Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case-control study.
    in International journal of infectious diseases
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Chiaretti A, Pulitanò S, Conti G, Barone G, Buonsenso D, Manni L, Capozzi D, Ria F, Riccardi R. (literal)
Pagina inizio
  • 241 (literal)
Pagina fine
  • 245 (literal)
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  • S1201-9712 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 13 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Largo Gemelli, 1, 00168, Rome, Italy Pediatric Intensive Care Unit, Catholic University of the Sacred Heart, A. Gemelli Hospital, Rome, Italy Institute of Translational Pharmacology, National Research Council (CNR), Rome, Italy Institute of General Pathology, Catholic University of the Sacred Heart, A. Gemelli Hospital, Rome, Italy (literal)
Titolo
  • Interleukin and neurotrophin up-regulation correlates with severity of H1N1 infection in children: a case-control study. (literal)
Abstract
  • OBJECTIVE: To evaluate the correlation between cytokine and neurotrophin expression and clinical findings, disease severity, and outcome of children with H1N1 influenza infection. METHODS: A prospective observational clinical study was performed on 15 children with H1N1 infection, 15 controls with lower respiratory tract infections (LRTI), and 15 non-infected children. Plasma levels of interleukin (IL)-1?, IL-6, and neurotrophic factor (nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and glial derived neurotrophic factor (GDNF)) were measured using immunoenzymatic assays. RESULTS: Significantly higher levels of IL-1?, IL-6, BDNF, and NGF were detected in patients with H1N1 infection compared to LRTI controls, while there was no significant variation in GDNF in the two groups. IL-1?, IL-6, BDNF, and NGF levels were significantly higher in H1N1 patients with more severe clinical manifestations compared to H1N1 patients with mild clinical manifestations. Of note, IL-6 was significantly correlated with the severity of respiratory compromise and fever, while NGF up-regulation was associated with the duration of cough. No correlation was found between interleukin and neurotrophic factor expression and outcome. CONCLUSIONS: H1N1 infection induces an early and significant IL-1?, IL-6, BDNF, and NGF up-regulation. The over-expression of these molecular markers is likely to play a neuroimmunomodulatory role in H1N1 infection and may contribute to airway inflammation and bronchial hyper-reactivity in infected children. (literal)
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