Lack of patent liver autoimmunity after breakage of tolerance in a mouse model. (Articolo in rivista)

Type
Label
  • Lack of patent liver autoimmunity after breakage of tolerance in a mouse model. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/intimm/dxg119 (literal)
Alternative label
  • Del Pozzo G, Mascolo D, Prisco A, Barba P, Anzisi A, Guardiola J. (2003)
    Lack of patent liver autoimmunity after breakage of tolerance in a mouse model.
    in International immunology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Del Pozzo G, Mascolo D, Prisco A, Barba P, Anzisi A, Guardiola J. (literal)
Pagina inizio
  • 1173 (literal)
Pagina fine
  • 1181 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 15 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Il lavoro indaga sulla rottura della tolleranza immunologica nei confronti di una proteina self quando essa e' fusa ad un epitopo T helper esogeno (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Genetics and Biophysics 'A. Buzzati Traverso', via G. Marconi 10, 80125, Naples, Italy Department of Oncology, National Institute for Cancer Research, Via M. Semmola, 80131 Naples, Italy (literal)
Titolo
  • Lack of patent liver autoimmunity after breakage of tolerance in a mouse model. (literal)
Abstract
  • We report in this work that a cellular and humoral autoreactive response can be induced against liver-specific self-determinants by repeated immunization with a chimeric tissue-specific self-antigen carrying a heterologous T(h) epitope. Epitope spreading rendering the autoimmune reaction independent of the presence of the cognate heterologous help is also demonstrated. Although neutrophil infiltrates can be demonstrated in the livers of treated mice, no clinical sign of organ damage is observed. These findings suggest that breakage of tolerance by this means leads the process only up to the next checkpoint in the progression of autoimmune disease and that further events are required to precipitate functional organ impairment. (literal)
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