http://www.cnr.it/ontology/cnr/individuo/prodotto/ID264030

Indole[1,2-c]quinazolines by palladium-catalyzed cyclization of bis(o-trifluoroacetamidophenyl) acetylene with aryl and vinyl halides or triflates (Articolo in rivista)

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Indole[1,2-c]quinazolines by palladium-catalyzed cyclization of bis(o-trifluoroacetamidophenyl) acetylene with aryl and vinyl halides or triflates (Articolo in rivista) (literal)

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Arcadi, A and Cacchi, S and Cassetta, A and Fabrizi, G and Parisi, LM (2001)
Indole[1,2-c]quinazolines by palladium-catalyzed cyclization of bis(o-trifluoroacetamidophenyl) acetylene with aryl and vinyl halides or triflates
in Synlett (Stuttg.); Thieme, Stuttgart (Germania)
(literal)

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Dipartimento Ingn. Chim & Mat, I-67100 Laquila, Italy; Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, I-00185 Rome, Italy; CNR, Ist. Cristallografia, I-34013 Trieste (literal)

Titolo

Indole[1,2-c]quinazolines by palladium-catalyzed cyclization of bis(o-trifluoroacetamidophenyl) acetylene with aryl and vinyl halides or triflates (literal)

Abstract

6-Trifluoromethyl-12-aryl(vinyl)indolo[1,2-c]quinazolines are prepared in high yield through the palladium-catalyzed reaction of readily available bis(o-trifluoroacetamidophenyl)acetylene with aryl or vinyl halides and triflates. followed by cyclization of the resultant derivatives. The reaction, which tolerates a variety of important functional groups. probably involves the formation of a 3-aryl-2-(o-trifluoroacetamidophenyl)indole intermediate, followed by its cyclization to the indolequinazoline product. Formation of the indoloquinazoline nucleus has been unambiguously determined via X-ray analysis. (literal)

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