Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. (Articolo in rivista)

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  • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/nn1037 (literal)
Alternative label
  • Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A (2003)
    Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.
    in Nature neuroscience (Print); Nature Publishing Group, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A (literal)
Pagina inizio
  • 453 (literal)
Pagina fine
  • 460 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 6 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. MRC Centre for Developmental Neurobiology, King's College London 2. Institute of Genetics and Biophysics, A. Buzzati-Traverso, CNR 3. IGBMC, 1 rue Laurent Fries, CU de Strasbourg, France 4. IST National Institute for Cancer Research, Universita' di Genova, 5. Dipartimento di Oncologia Clinica e Sperimentale, Universita' di Genova 6. GSF Research Center, Institute of Developmental Genetics, Max-Planck-Institute of Psychiatry, Molecular Neurogenetics (literal)
Titolo
  • Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. (literal)
Abstract
  • Organizing centers emit signaling molecules that specify different neuronal cell types at precise positions along the anterior-posterior (A-P) and dorsal-ventral (D-V) axes of neural tube during development. Here we report that reduction in Otx proteins near the alar-basal plate boundary (ABB) of murine midbrain resulted in a dorsal shift of Shh expression, and reduction in Otx proteins at the midbrain-hindbrain boundary (MHB) resulted in an anterior expansion of the Fgf8 domain. Our data thus indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression. Furthermore, this control is effective for conferring proper cell identity in the floor-plate region of midbrain and does not require an Otx2-specific property. We propose that this mechanism may provide both A-P and D-V positional information to neuronal precursors located within the midbrain. (literal)
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