Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Forabosco P; Gorman JD; Cleveland C; Kelly JA; Fisher SA; Ortmann WA; Johansson C; Johanneson B; Moser KL; Gaffney PM; Tsao BP; Cantor RM; Alarcon-Riquelme ME; Behrens TW; Harley JB; Lewis CM; Criswell LA (2006)
  Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus.
  in Genes and immunity
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Forabosco P; Gorman JD; Cleveland C; Kelly JA; Fisher SA; Ortmann WA; Johansson C; Johanneson B; Moser KL; Gaffney PM; Tsao BP; Cantor RM; Alarcon-Riquelme ME; Behrens TW; Harley JB; Lewis CM; Criswell LA (literal)

Pagina inizio

• 609 (literal)

Pagina fine

• 614 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Genes and immunity (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Medical and Molecular Genetics, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK Istituto di Genetica delle Popolazioni-CNR, Alghero, Italy Section of Rheumatology, Virginia Mason Medical Center, Seattle, WA, USA Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA Oklahoma Medical Research Foundation, Oklahoma City, OK, USA Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA Departments of Human Genetics and Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Oklahoma Medical Research Foundation, University of Oklahoma, Oklahoma City, OK, USA US Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA (literal)

Titolo

• Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. (literal)

Abstract

• A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1-q15 and 20p11-q13.13 (P-value=0.0056 and P-value=0.0044, respectively) and a region with P-value<0.01 on 16p13-q12.2.The region on chromosome 6 contains the human leukocyte antigen cluster, and the chromosome 16 and 20 regions have been replicated in several cohorts. The potential importance of the identified genomic regions are also highlighted. These results, in conjunction with data emerging from dense single nucleotide polymorphism typing of specific regions or future genome-wide association studies will help guide efforts to identify the actual predisposing genetic variation contributing to this complex genetic disease. (literal)

Prodotto di

• Identificazione di geni-malattia mediante genotipizzazione ad alta densità di popolazioni. (SV.P18.001.002) (Modulo)
• Institute of population genetics (IGP) (Istituto)

Autore CNR

• PAOLA FORABOSCO (Unità di personale interno)

Incoming links:

Autore CNR di

• PAOLA FORABOSCO (Unità di personale interno)

Prodotto

• Institute of population genetics (IGP) (Istituto)
• Identificazione di geni-malattia mediante genotipizzazione ad alta densità di popolazioni. (SV.P18.001.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genes and immunity (Rivista)