Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0090-4295(03)00473-4 (literal)

Alternative label

• Ombra MN, Casula S, Biino G, Maestrale G, Cardia F, Melis P, Pirastu M. (2003)
  Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate.
  in Urology (Ridgewood N.J.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ombra MN, Casula S, Biino G, Maestrale G, Cardia F, Melis P, Pirastu M. (literal)

Pagina inizio

• 416 (literal)

Pagina fine

• 420 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 62 (literal)

Rivista

• Urology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Genetica delle Popolazioni, CNR Alghero; and SharDNA Life Science, Cagliari, Italy (literal)

Titolo

• Urinary glycosaminoglycans as risk factors for uric acid nephrolithiasis: case control study in a Sardinian genetic isolate. (literal)

Abstract

• OBJECTIVES: To assess the clinical association between glycosaminoglycan (GAG) excretion and uric acid (UA) nephrolithiasis by measuring urinary GAG levels in a case-control study conducted in a Sardinian genetic isolate. Inhibitors of crystallization such as GAGs seem to be involved in kidney stone formation. METHODS: Overnight (12-hour) urinary excretion of GAGs, calcium, oxalate, and UA were measured in urine samples from 60 patients who had formed at least one urinary stone (UA or mixed) and 52 healthy controls. The total GAG concentration was measured by a dye-binding assay, and the values were normalized against creatinine to obtain values in micrograms of GAG per milligram creatinine. Statistical analysis was performed using t tests and logistic regression analysis. RESULTS: No significant difference was found between the two groups with respect to calcium and oxalate concentrations. Nonetheless, stone formers had significantly lower levels of GAGs (29.5 +/- 2.2 versus 36.4 +/- 3.9 microg/mg creatinine, P = 0.003) and greater levels of UA (385.11 +/- 38.2 versus 298.43 +/- 31.4 mg/12 hr, P = 0.0010) than did the normal controls. CONCLUSIONS: We report that the lower excretion of GAGs in stone formers could impair their inhibitory activity on UA stone formation, and, as a consequence, it may represent a risk factor for this form of urolithiasis. (literal)

Prodotto di

• Institute of population genetics (IGP) (Istituto)

Autore CNR

• GIOVANNI BATTISTA MAESTRALE (Unità di personale interno)
• STEFANIA CASULA (Persona)
• GINEVRA BIINO (Persona)
• PAOLA MARIA MELIS (Persona)
• MARIO PIRASTU (Unità di personale interno)
• MARIA NEVE OMBRA (Persona)

Incoming links:

Autore CNR di

• MARIO PIRASTU (Unità di personale interno)
• MARIA NEVE OMBRA (Persona)
• GINEVRA BIINO (Persona)
• PAOLA MARIA MELIS (Persona)
• STEFANIA CASULA (Persona)
• GIOVANNI BATTISTA MAESTRALE (Unità di personale interno)

Prodotto

• Institute of population genetics (IGP) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Urology (Rivista)