Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory (Articolo in rivista)

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Label
  • Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neurobiolaging (literal)
Alternative label
  • Andrea Pristerà a; Daniele Saraulli b; Stefano Farioli-Vecchioli a; Georgios Strimpakos a; Marco Costanzi a, c; Maria Grazia di Certo a; Sara Cannas a; Maria Teresa Ciotti a; Felice Tirone a; Elisabetta Mattei a; Vincenzo Cestari a, d; Nadia Canu e, f (2013)
    Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory
    in Neurobiology of aging
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Andrea Pristerà a; Daniele Saraulli b; Stefano Farioli-Vecchioli a; Georgios Strimpakos a; Marco Costanzi a, c; Maria Grazia di Certo a; Sara Cannas a; Maria Teresa Ciotti a; Felice Tirone a; Elisabetta Mattei a; Vincenzo Cestari a, d; Nadia Canu e, f (literal)
Pagina inizio
  • 2551 (literal)
Pagina fine
  • 2563 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Epub 2013 Jun 12 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 34 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Institute of Cellular Biology and Neurobiology, National Research Council and Fondazione Santa Lucia, Rome, Italy. b Department of Psychology, Sapienza University of Rome, Rome, Italy. c Department of Human Sciences Libera Universitá Maria Santissima Assunta (LUMSA), Rome, Italy. d Department of Psychology and \"Daniel Bovet \" Center, Sapienza University of Rome, Rome, Italy. e Department of System Medicine, University of Rome \"Tor Vergata \", Rome, Italy. f Institute of Cellular Biology and Neurobiology, National Research Council, Rome, Italy. (literal)
Titolo
  • Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory (literal)
Abstract
  • Different pathological tau species are involved in memory loss in Alzheimer's disease, the most common cause of dementia among older people. However, little is known about how tau pathology directly affects adult hippocampal neurogenesis, a unique form of structural plasticity implicated in hippocampus-dependent spatial learning and mood-related behavior. To this aim, we generated a transgenic mouse model conditionally expressing a pathological tau fragment (26-230 aa of the longest human tau isoform, or N-tau) in nestin-positive stem/progenitor cells. We found that N-tau reduced the proliferation of progenitor cells in the adult dentate gyrus, reduced cell survival and increased cell death by a caspase-3-independent mechanism, and recruited microglia. Although the number of terminally differentiated neurons was reduced, these showed an increased dendritic arborization and spine density. This resulted in an increase of anxiety-related behavior and an impairment of episodic-like memory, whereas less complex forms of spatial learning remained unaltered. Understanding how pathological tau species directly affect neurogenesis is important for developing potential therapeutic strategies to direct neurogenic instructive cues for hippocampal function repair. (literal)
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