http://www.cnr.it/ontology/cnr/individuo/prodotto/ID261519
Electrophysiological variability in the SH-SY5Y cellular line (Articolo in rivista)
- Type
- Label
- Electrophysiological variability in the SH-SY5Y cellular line (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.4149/gpb_2013071 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Santillo S., A. Schiano Moriello and V. Di Maio (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.ncbi.nlm.nih.gov/pubmed/?term=santillo (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Santillo Silvia, ICIB - Istituto di Cibernetica \"Edoardo Caianiello\"
Di Maio Vito, ICIB - Istituto di Cibernetica \"Edoardo Caianiello\"
Sciano Moriello Aniello, ICB - Istituto di Chimica biomolecolare (literal)
- Titolo
- Electrophysiological variability in the SH-SY5Y cellular line (literal)
- Abstract
- The basic electrophysiological properties of SH-SY5Y tumour cells have been studied by
whole cell patch-clamp in voltage clamp configuration. The results shown the existence of a
large variability of the response among individual cells in the same experimental conditions.
Experiments conducted by using different ionic concentrations of the recording pipette filling
solution, yielded a significant variability of peak current amplitude for all the filling solutions
used. In addition, variability among groups was detected. The inter-group variability was not
dependent on the different ionic components among the groups. Our results confirm earlier
findings that this cell line is not constituted of an uniform population of cells. Moreover, from
the present results we can conclude that these cells have diverse regulatory patterns of
membrane conductance, probably due to both the expression as well as a non precise
regulation of the membrane density of the different channels. (literal)
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