http://www.cnr.it/ontology/cnr/individuo/prodotto/ID261456
Luminescent zinc salophen derivatives: cytotoxicity assessment and action mechanism studies+ (Articolo in rivista)
- Type
- Label
- Luminescent zinc salophen derivatives: cytotoxicity assessment and action mechanism studies+ (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/c3nj41125g (literal)
- Alternative label
R. Brissos, D. Ramos, J. C. Lima, F. Yafteh Mihan,
M. Borras, J. de Lapuente, A. Dalla Cort, L. Rodriguez (2013)
Luminescent zinc salophen derivatives: cytotoxicity assessment and action mechanism studies+
in New journal of chemistry (1987); RSC Publishing, Cambridge (Regno Unito)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- R. Brissos, D. Ramos, J. C. Lima, F. Yafteh Mihan,
M. Borras, J. de Lapuente, A. Dalla Cort, L. Rodriguez (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.rsc.org/njc (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Scopus (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Departament de Quimica Inorganica, Universitat de Barcelona, Mart?i Franques
1-11, 08028 Barcelona, Spain.
Unitat de Toxicologia Experimental i Ecotoxicologia. Parc Cientific de Barcelona,
c/Baldiri i Reixach, 10-12, 08028 Barcelona, Spain.
REQUIMTE. Departamento de Quimica, Faculdade de Ciencias e Tecnologia,
Universidade Nova de Lisboa, 2829-516 Monte de Caparica, Portugal
Dipartimento di Chimica and IMC-CNR Sezione Meccanismi di Reazione,
Universita` La Sapienza, Box 34 Roma 62, 00185 Roma, Italy. (literal)
- Titolo
- Luminescent zinc salophen derivatives: cytotoxicity assessment and action mechanism studies+ (literal)
- Abstract
- The biological activity of two fluorescent Zn(II)-salophen derivatives has been evaluated. In vitro studies
(AFM, emission and UV-vis titration with ethidium bromide and cell growth inhibition) show different
mechanisms of interaction with DNA. It has been observed that these compounds enter the cells.
Comet assays (with cultured fibroblast cells) have revealed that cellular uptake occurs without
damaging the DNA strands. Preliminary studies carried out with living cells have shown IC50 values in a
millimolar range, indicative of a non-cytotoxic behaviour. This fact could be understood by confocal
microscopy co-localization studies with living cell internalization that have shown that, in fact, the
compounds seem to enter the cells but not the nucleus under in vivo conditions. (literal)
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