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Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation (Articolo in rivista)
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- Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbamem.2012.10.021 (literal)
- Alternative label
R. Cosimati, G.L. Milardi, C. Bombelli, A. Bonincontro, F. Bordi, G. Mancini, G. Risuleo (2013)
Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation
in Biochimica et biophysica acta. G, General subjects (Print); Elsevier, Amsterdam (Paesi Bassi)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- R. Cosimati, G.L. Milardi, C. Bombelli, A. Bonincontro, F. Bordi, G. Mancini, G. Risuleo (literal)
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- http://www.elsevier.com (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- Dipartimento di Fisica, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy
Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy
CNR, Istituto di Metodologie Chimiche, Dipartimento di Chimica, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy
CNR-IPCF, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy (literal)
- Titolo
- Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation (literal)
- Abstract
- The electrorotation technique was utilized to investigate the interactions between a mouse fibroblast cell line
and zwitterionic liposomes formed by a natural phospholipid or cationic liposomes formulated with the same
phospholipid and a cationic gemini surfactant. The application of this technique allowed an accurate characterization
of the passive dielectric behavior of the plasmamembrane by the determination of its specific capacitance
and conductance. Changes of these parameters, upon interaction with the liposomes, are related to variations in
the structure and or in the transport properties of the membrane. Cells were exposed to both types of liposomes
for 1 or 4 h. Electrorotation data showa dramatic reduction of the dielectric parameters of the plasma membrane
after one hour treatment. After 4 h of treatment the effects are still observed only in the case of the cationic liposomes.
Surprisingly, these same treatments did not cause a relevant biological damage as assessed by standard
viability tests. A detailed discussion to rationalize this phenomenon is presented. (literal)
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