Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation (Articolo in rivista)

Type
Label
  • Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbamem.2012.10.021 (literal)
Alternative label
  • R. Cosimati, G.L. Milardi, C. Bombelli, A. Bonincontro, F. Bordi, G. Mancini, G. Risuleo (2013)
    Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation
    in Biochimica et biophysica acta. G, General subjects (Print); Elsevier, Amsterdam (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • R. Cosimati, G.L. Milardi, C. Bombelli, A. Bonincontro, F. Bordi, G. Mancini, G. Risuleo (literal)
Pagina inizio
  • 352 (literal)
Pagina fine
  • 356 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.elsevier.com (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1828 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Fisica, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy CNR, Istituto di Metodologie Chimiche, Dipartimento di Chimica, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy CNR-IPCF, Sapienza Università di Roma, P. Aldo Moro 5, 00185, Roma, Italy (literal)
Titolo
  • Interactions of DMPC and DMPC/gemini liposomes with the cell membrane investigated by electrorotation (literal)
Abstract
  • The electrorotation technique was utilized to investigate the interactions between a mouse fibroblast cell line and zwitterionic liposomes formed by a natural phospholipid or cationic liposomes formulated with the same phospholipid and a cationic gemini surfactant. The application of this technique allowed an accurate characterization of the passive dielectric behavior of the plasmamembrane by the determination of its specific capacitance and conductance. Changes of these parameters, upon interaction with the liposomes, are related to variations in the structure and or in the transport properties of the membrane. Cells were exposed to both types of liposomes for 1 or 4 h. Electrorotation data showa dramatic reduction of the dielectric parameters of the plasma membrane after one hour treatment. After 4 h of treatment the effects are still observed only in the case of the cationic liposomes. Surprisingly, these same treatments did not cause a relevant biological damage as assessed by standard viability tests. A detailed discussion to rationalize this phenomenon is presented. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it