http://www.cnr.it/ontology/cnr/individuo/prodotto/ID260797

Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent (Articolo in rivista)

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Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent (Articolo in rivista) (literal)

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Hosseini F. [ 1 ] ; Panahifar A. [ 2 ] ; Adeli M. [ 1,3 ] ; Amiri H. [ 4,5,6 ] ; Lascialfari A. [ 4,5,6 ] ; Orsini F. [ 4,5 ] ; Doschak M. R.[ 2,7 ] ; Mahmoudi M. [ 8,9 ] (2013)
Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent
in Colloids and surfaces. B, Biointerfaces (Print); ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Hosseini F. [ 1 ] ; Panahifar A. [ 2 ] ; Adeli M. [ 1,3 ] ; Amiri H. [ 4,5,6 ] ; Lascialfari A. [ 4,5,6 ] ; Orsini F. [ 4,5 ] ; Doschak M. R.[ 2,7 ] ; Mahmoudi M. [ 8,9 ] (literal)

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[ 1 ] Payame Noor Univ, Dept Chem, Tehran, Iran [ 2 ] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2E1, Canada [ 3 ] Sharif Univ Technol, Dept Chem, Tehran, Iran [ 4 ] Univ Milan, Dipartimento Sci Mol Applicate Biosistemi, I-20134 Milan, Italy [ 5 ] CNR Ist Nanosci, Ctr S3, I-41100 Modena, Italy [ 6 ] Univ Pavia, Dipartimento Fis A Volta, I-27100 Pavia, Italy [ 7 ] Univ Alberta, Fac Med, Dept Biomed Engn, Edmonton, AB T6G 2E1, Canada [ 8 ] Univ Tehran Med Sci, Fac Pharm, Dept Nanotechnol, Tehran, Iran [ 9 ] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran (literal)

Titolo

Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent (literal)

Abstract

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of alpha-cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the H-1 Nuclear Magnetic Resonance (NMR) relaxation times T-1 and T-2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem (R), showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem and can be considered as a novel MRI contrast agent. (literal)

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