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Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny (Articolo in rivista)

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Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny (Articolo in rivista) (literal)

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Francalacci P, Morelli L, Angius A, Berutti R, Reinier R, Sidore C, Zara I, Sanna D, Useli A, Busonero F, Maschio A, Urru MF, Marcelli M, Cusano R, Oppo M, Zoledziewska M, Pitzalis M, Deidda F, Poddie F, Kang HM, Li B, Usala G, Piras MG, Lobina M, Mulas A, Dei M, Lai S, Whalen MB, Uzzau S, Schlessinger D, Abecasis GR, Jones C, Sanna S, Cucca F (2013)
Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny
in Science (New York, N.Y.); AAAS, American association for the advancement of science, Washington, DC (Stati Uniti d'America)
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Francalacci P, Morelli L, Angius A, Berutti R, Reinier R, Sidore C, Zara I, Sanna D, Useli A, Busonero F, Maschio A, Urru MF, Marcelli M, Cusano R, Oppo M, Zoledziewska M, Pitzalis M, Deidda F, Poddie F, Kang HM, Li B, Usala G, Piras MG, Lobina M, Mulas A, Dei M, Lai S, Whalen MB, Uzzau S, Schlessinger D, Abecasis GR, Jones C, Sanna S, Cucca F (literal)

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Dipartimento di Scienze della Natura e del Territorio, Università di Sassari, 07100 Sassari, Italy. Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Monserrato, Italy. Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy. Dipartimento di Scienze Biomediche, Università di Sassari, 07100 Sassari, Italy. Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA. DNA Sequencing Core, University of Michigan, Ann Arbor, MI 48109, USA. Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235, USA. Dipartimento di Biologia, Universitàdi Pisa, 56126 Pisa, Italy. Departamento de Genética, Antropología Física y Fisiología Animal, Universidad del País Vasco/Euskal Herriko Unibertsitatea, 48080 Bilbao, Spain. Porto Conte Ricerche, Località Tramariglio, Alghero, 07041 Sassari, Italy. Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA. (literal)

Titolo

Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny (literal)

Abstract

Genetic variation within the male-specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1204 Sardinian males identified 11,763 MSY single-nucleotide polymorphisms, 6751 of which have not previously been observed. We constructed a MSY phylogenetic tree containing all main haplogroups found in Europe, along with many Sardinian-specific lineage clusters within each haplogroup. The tree was calibrated with archaeological data from the initial expansion of the Sardinian population ~7700 years ago. The ages of nodes highlight different genetic strata in Sardinia and reveal the presumptive timing of coalescence with other human populations. We calculate a putative age for coalescence of ~180,000 to 200,000 years ago, which is consistent with previous mitochondrial DNA-based estimates. (literal)

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