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Involvement of ryanodine receptors in spc-induced calcium release from brain microsomes. (Articolo in rivista)

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Involvement of ryanodine receptors in spc-induced calcium release from brain microsomes. (Articolo in rivista) (literal)

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C. Dettbarn, R. Betto, G. Salviati, R. Sabbadini, P.T. Palade. (1995)
Involvement of ryanodine receptors in spc-induced calcium release from brain microsomes.
in Brain research
(literal)

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Department of Physiology and Biophisics, University of Texas Medical Branch at Galveston; Department of Biology and Molecular Biology Institute, San Diego State University; Department of Biomedical Sciences, University of Padova (literal)

Titolo

Involvement of ryanodine receptors in spc-induced calcium release from brain microsomes. (literal)

Abstract

Sphingosylphosphorylcholine (SPC) releases Ca2+ from brain microsomes. SPC-induced CA2+ release differs from IP3-induced Ca2+ release in that it is more extensive in the cerebrum than in the cerebellum. SPC has little effect on [3H] IP3 binding but enhances [3H] ryanodine binding, as expected for an activator of ryanodine receptors. SPC-induced Ca2+ release is inhibited by ryanodine receptor blockers but not by selective blockers of IP3 receptors. We conclude that SPC releases Ca2+ from brain microsomes by activating ryanodine receptors rather than IP3 receptors. Activation of an additional SPC-sensitive pathway for releasing Ca2+ is not precluded. (literal)

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