http://www.cnr.it/ontology/cnr/individuo/prodotto/ID260415

gamma-Hemolysin oligomeric structure and effect of its formation on supported lipid bilayers: An AFM Investigation (Articolo in rivista)

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gamma-Hemolysin oligomeric structure and effect of its formation on supported lipid bilayers: An AFM Investigation (Articolo in rivista) (literal)

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Alessandrini A. [ 1,2 ] ; Viero G. [ 3,4 ] ; Dalla Serra M. [ 3,4 ] ; Prevost G. [ 5 ] ; Facci P. [ 1 ] (2013)
gamma-Hemolysin oligomeric structure and effect of its formation on supported lipid bilayers: An AFM Investigation
in Biochimica et biophysica acta. Biomembranes; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Alessandrini A. [ 1,2 ] ; Viero G. [ 3,4 ] ; Dalla Serra M. [ 3,4 ] ; Prevost G. [ 5 ] ; Facci P. [ 1 ] (literal)

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[ 1 ] CNR Ist Nanosci, Ctr S3, I-41125 Modena, Italy [ 2 ] Univ Modena & Reggio Emilia, Dept Phys, I-41125 Modena, Italy [ 3 ] CNR Inst Biophys, I-38123 Trento, Italy [ 4 ] Bruno Kessler Fdn, I-38123 Trento, Italy [ 5 ] UR EA Physiopathol & Med Translat, Inst Bacteriol, Fac Med, F-67000 Strasbourg, France (literal)

Titolo

gamma-Hemolysin oligomeric structure and effect of its formation on supported lipid bilayers: An AFM Investigation (literal)

Abstract

gamma-Hemolysins are bicomponent beta-barrel pore forming toxins produced by Staphylococcus aureus as water-soluble monomers, which assemble into oligomeric pores on the surface of lipid bilayers. Here, after investigating the oligomeric structure of gamma-hemolysins on supported lipid bilayers (SLBs) by atomic force microscopy (AFM), we studied the effect produced by this toxin on the structure of SLBs. We found that oligomeric structures with different number of monomers can assemble on the lipid bilayer being the octameric form the stablest one. Moreover, in this membrane model we found that gamma-hemolysins can form clusters of oligomers inducing a curvature in the lipid bilayer, which could probably enhance the aggressiveness of these toxins at high concentrations. (literal)

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