http://www.cnr.it/ontology/cnr/individuo/prodotto/ID254868
SPECTROSCOPIC STUDY OF HYDROXYPROLINE TRANSPORT IN RAT-KIDNEY MITOCHONDRIA (Articolo in rivista)
- Type
- Label
- SPECTROSCOPIC STUDY OF HYDROXYPROLINE TRANSPORT IN RAT-KIDNEY MITOCHONDRIA (Articolo in rivista) (literal)
- Anno
- 1994-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1006/bbrc.1994.1893 (literal)
- Alternative label
ATLANTE, A; PASSARELLA, S; QUAGLIARIELLO, E (1994)
SPECTROSCOPIC STUDY OF HYDROXYPROLINE TRANSPORT IN RAT-KIDNEY MITOCHONDRIA
in Biochemical and biophysical research communications (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- ATLANTE, A; PASSARELLA, S; QUAGLIARIELLO, E (literal)
- Pagina inizio
- Pagina fine
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- http://www.scopus.com/record/display.url?eid=2-s2.0-0028048282&origin=inward (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WoS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- UNIV MOLISE; University of Bari (literal)
- Titolo
- SPECTROSCOPIC STUDY OF HYDROXYPROLINE TRANSPORT IN RAT-KIDNEY MITOCHONDRIA (literal)
- Abstract
- Hydroxyproline uptake by rat kidney mitochondria is here first shown by monitoring the reduction of the intramitochondrial pyridine nucleotides which occurs as a result of metabolism of imported hydroxyproline via hydroxyproline oxidase and 3-hydroxy-pyrroline-5-carboxylate dehydrogenase. Widely used criteria for demonstrating the occurrence of carrier-mediated transport were applied to this process. Hydroxyproline uptake shows saturation features (Km and Vmax values, measured at 20 degrees C and at pH 7.20, were found to be about 1.4 mM and 5 nmoles/min x mg mitochondrial protein, respectively) and proves to be inhibited by the impermeable compound phenylsuccinate, but insensitive to externally added methylglutamate. Difference found in the Km and Vmax values, a different inhibitor sensitivity and the failure of hydroxyproline to cause efflux of glutamate from the mitochondria show that hydroxyproline enters mitochondria by means of a translocator different from those which transport proline. (C) 1944 Academic Press, Inc. (literal)
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- Autore CNR
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