Glutamine transport in normal and acidotic rat kidney mitochondria (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Glutamine transport in normal and acidotic rat kidney mitochondria (Articolo in rivista) (literal)

Anno

• 1994-01-01T00:00:00+01:00 (literal)

Alternative label

• ATLANTE A, PASSARELLA S, MINERVINI GM, QUAGLIARIELLO E (1994)
  Glutamine transport in normal and acidotic rat kidney mitochondria
  in Archives of biochemistry and biophysics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• ATLANTE A, PASSARELLA S, MINERVINI GM, QUAGLIARIELLO E (literal)

Pagina inizio

• 369 (literal)

Pagina fine

• 381 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 315 (literal)

Rivista

• Archives of biochemistry and biophysics (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Centro di Studio sui Mitocondri e Metabolismo Energetico, CNR, Bari - Italy Dipartimento di Biochimica e Biologia Molecolare, Università di Ban, Bari, Italy (literal)

Titolo

• Glutamine transport in normal and acidotic rat kidney mitochondria (literal)

Abstract

• Glutamine transport in both normal and acidotic rat kidney mitochondria was investigated using both isotopic techniques and by spectroscopic measurements in which glutamine metabolism was allowed to occur. Widely used criteria for demonstrating the occurrence of carrier-mediated transport were successfully applied in both cases. Three transport mechanisms were found to occur, namely glutamine uniport, active only during acidosis and glutamine/glutamate and glutamine/malate antiports, active in both normal and acidotic mitochondria. Efflux of glutamate, via a glutamate/OH- translocator, following glutamine uptake by mitochondria was experimentally ruled out. Glutamine uniport in acidotic mitochondria and glutamine/glutamate and glutamine/malate antiports in both normal and acidotic mitochondria were investigated in detail: differences found in Km and Vmax values, in pH and temperature dependence, and in the pattern of inhibitor sensitivity of glutamine transport demonstrated the existence of five different translocators whose activities were found to fit with the physiological requirements of renal ammoniogenesis. (literal)

Prodotto di

• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)
• Institute of biomembrane and bioenergetics (IBBE) (Istituto)

Autore CNR

• ANNA ATLANTE (Unità di personale interno)

Incoming links:

Prodotto

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR di

• ANNA ATLANTE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Archives of biochemistry and biophysics (Rivista)