AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling (Articolo in rivista)

Type
Label
  • AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling (Articolo in rivista) (literal)
Anno
  • 1998-01-01T00:00:00+01:00 (literal)
Alternative label
  • ATLANTE A, PASSARELLA S (1998)
    AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling
    in International Journal of Molecular Medicine
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • ATLANTE A, PASSARELLA S (literal)
Pagina inizio
  • 601 (literal)
Pagina fine
  • 604 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • ISSN: 1107-3756 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Centro di Studio sui Mitocondri e Metabolismo Energetico, CNR, 70126 Bari, Italy. (literal)
Titolo
  • AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling (literal)
Abstract
  • The mitochondrial myopathy associated with long-term AZT therapy limits the clinical efficacy of this drug in AIDS therapy. Thus, in order to determine how AZT can affect mitochondria bioenergetics, the capability of AZT to both uncouple oxidative phosphorylation and inhibit electron flow in isolated rat liver mitochondria was investigated. The failure of AZT to oxidize intramitochondrial pyridine nucleotides, to stimulate mitochondrial swelling in K+-acetate plus valinomycin or to cause ATP hydrolysis shows that AZT is not an uncoupler. (literal)
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