ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL-LINES VIA DRUG PHOTOACTIVATION (Articolo in rivista)

Type
Label
  • ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL-LINES VIA DRUG PHOTOACTIVATION (Articolo in rivista) (literal)
Anno
  • 1993-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1751-1097.1993.tb09223.x (literal)
Alternative label
  • ANDREONI, A 1; COLASANTI, A 3; KISSLINGER, A 2; MASTROCINQUE, M 2; PORTELLA, G 2; RICCIO, P 3; ROBERTI, G 3 (1993)
    ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL-LINES VIA DRUG PHOTOACTIVATION
    in Photochemistry and photobiology; J. Wiley & sons, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • ANDREONI, A 1; COLASANTI, A 3; KISSLINGER, A 2; MASTROCINQUE, M 2; PORTELLA, G 2; RICCIO, P 3; ROBERTI, G 3 (literal)
Pagina inizio
  • 851 (literal)
Pagina fine
  • 855 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 57 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • [ 1 ] UNIV NAPLES,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC,I-80131 NAPLES,ITALY [ 2 ] FDN SEN G PASCALE,IST NAZL STUDIO & CURA TUMORI,I-80131 NAPLES,ITALY [ 3 ] UNIV NAPLES,DIPARTIMENTO SCI FIS,I-80125 NAPLES,ITALY (literal)
Titolo
  • ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL-LINES VIA DRUG PHOTOACTIVATION (literal)
Abstract
  • We have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (Fisher rat thyroid cells, FRTL-5) and to two neoplastic cell lines, a thyroid carcinoma (TK-6) and its lung metastasis (MPTK-6). Whereas the cell lines are equally sensitive to the drug in the dark, if irradiated during incubation with daunomycin (86 J/cm2 at 488 nm), they become more and differently sensitive. Namely, the drug doses producing 50% mortality decrease by factors of about 22, 28 and 16 for FRTL-5, TK-6 and MPTK-6 cell lines, respectively. This result correlates with differences in drug uptake and resistance observed in the normal and neoplastic cell lines. (literal)
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