http://www.cnr.it/ontology/cnr/individuo/prodotto/ID254343
Kinetic transport analysis of daunorubicin by LoVo and LoVo/DX cells (Articolo in rivista)
- Type
- Label
- Kinetic transport analysis of daunorubicin by LoVo and LoVo/DX cells (Articolo in rivista) (literal)
- Anno
- 1996-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1751-1097.1996.tb02436.x (literal)
- Alternative label
Andreoni, A 1,2; Colasanti, A. 1,3, Kisslinger, A 1, Mastrocinque, M 1, Riccio, P 3,Roberti, G 4 (1996)
Kinetic transport analysis of daunorubicin by LoVo and LoVo/DX cells
in Photochemistry and photobiology; J. Wiley & sons, New York (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Andreoni, A 1,2; Colasanti, A. 1,3, Kisslinger, A 1, Mastrocinque, M 1, Riccio, P 3,Roberti, G 4 (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- [ 1 ] UNIV NAPLES,CNR,CTR ENDOCRINOL & ONCOL SPERIMENTALE,NAPLES,ITALY
[ 2 ] UNIV MILAN,IST SCI MATEMAT FIS & CHIM,COMO,ITALY
[ 3 ] UNIV NAPLES,DIPARTIMENTO BIOL & PATOL CELLULARE & MOL,NAPLES,ITALY
[ 4 ] UNIV NAPLES,DIPARTIMENTO SCI FISICHE,NAPLES,ITALY (literal)
- Titolo
- Kinetic transport analysis of daunorubicin by LoVo and LoVo/DX cells (literal)
- Abstract
- We describe a fluorometric technique for the measurement of transport parameters of fluorescent drugs through cellular membranes. Unlike other procedures, this method gives an accurate measure of drug accumulated in the cells and measures the fraction of free and bound drug in the cell. The kinetic parameters of transport through cellular membranes are determined using a simple three-compartment model combined with fluorescence measurements performed on the extracellular medium and on Triton-permeabilized cells during daunorubicin incorporation. With this technique we found that LoVo cells have a greater daunorubicin uptake, a similar input rate constant and a lower output rate constant than the drug-resistant LoVo/DX cells. (literal)
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