http://www.cnr.it/ontology/cnr/individuo/prodotto/ID252894
Adaptive response in human blood lymphocytes exposed to non-ionizing radiofrequency fields: resistance to ionizing radiation-induced damage (Articolo in rivista)
- Type
- Label
- Adaptive response in human blood lymphocytes exposed to non-ionizing radiofrequency fields: resistance to ionizing radiation-induced damage (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1093/jrr/rrt106 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Anna Sannino; Olga Zeni; Stefania Romeo; Rita Massa; Giancarlo Gialanella; Gianfranco Grossi; Lorenzo Manti; Vijayalaxmi; Maria Rosaria Scarfi (literal)
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- 1CNR - Institute for Electromagnetic Sensing of the Environment, via Diocleziano 328, 80124, Napoli, Italy
2National Institute of Nuclear Physics, Section of Napoli, via Cintia, 80126, Napoli, Italy
3Department of Physics, University of Naples Federico II, CMSAvia Cintia, 80126, Napoli, Italy
4Centre of Radioprotection and Health Physics, University of Naples Federico II, via Cintia, 80126, Napoli, Italy
5Department of Radiology, University of Texas Health Science Centre, 7703 Floyd Curl Drive - MC 7800, San Antonio,
TX 78229-3900, USA (literal)
- Titolo
- Adaptive response in human blood lymphocytes exposed to non-ionizing radiofrequency fields: resistance to ionizing radiation-induced damage (literal)
- Abstract
- The aim of this preliminary investigation was to assess whether human peripheral blood lymphocytes which
have been pre-exposed to non-ionizing radiofrequency fields exhibit an adaptive response (AR) by resisting
the induction of genetic damage from subsequent exposure to ionizing radiation. Peripheral blood lymphocytes
from four healthy donors were stimulated with phytohemagglutinin for 24 h and then exposed for 20 h
to 1950 MHz radiofrequency fields (RF, adaptive dose, AD) at an average specific absorption rate of 0.3 W/kg.
At 48 h, the cells were subjected to a challenge dose (CD) of 1.0 or 1.5 Gy X-irradiation (XR, challenge dose,
CD). After a 72 h total culture period, cells were collected to examine the incidence of micronuclei (MN).
There was a significant decrease in the number of MN in lymphocytes exposed to RF + XR (AD + CD)
as compared with those subjected to XR alone (CD). These observations thus suggested a RF-induced AR
and induction of resistance to subsequent damage from XR. There was variability between the donors in
RF-induced AR. The data reported in our earlier investigations also indicated a similar induction of AR in
human blood lymphocytes that had been pre-exposed to RF (AD) and subsequently treated with a chemical
mutagen, mitomycin C (CD). Since XR and mitomycin-C induce different kinds of lesions in cellular DNA,
further studies are required to understand the mechanism(s) involved in the RF-induced adaptive response. (literal)
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