Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans (Articolo in rivista)

Type
Label
  • Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbamem.2012.12.013 (literal)
Alternative label
  • Conti Stefania Radicioni Giorgia Ciociola Tecla Longhi Renato Polonelli Luciano Gatti Rita Cabras Tiziana Messana Irene Castagnola Massimo Vitali Alberto (2013)
    Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans
    in Biochimica et biophysica acta. Biomembranes
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Conti Stefania Radicioni Giorgia Ciociola Tecla Longhi Renato Polonelli Luciano Gatti Rita Cabras Tiziana Messana Irene Castagnola Massimo Vitali Alberto (literal)
Pagina inizio
  • 1066 (literal)
Pagina fine
  • 1074 (literal)
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  • http://dx.doi.org/10.1016/j.bbamem.2012.12.013 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1828 (literal)
Rivista
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  • 8 (literal)
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  • 3 (literal)
Note
  • Science direct - Elsevier (literal)
  • Google Scholar (literal)
  • PubMe (literal)
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  • Conti Stefania, Polonelli Luciano, Ciociola Tecla: Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali, Unità di Microbiologia e Virologia, University of Parma, via Volturno 39, 43126, Parma, Italy Radicioni Giorgia, Castagnola Massimo: Istituto di Biochimica e Biochimica Clinica, Faculty of Medicine, Catholic University, L.go F. Vito 1, 00168 Rome, Italy Longhi Renato: Istituto di Chimica per il Riconoscimento Molecolare, Italian National Research Council (CNR), via Mario Bianco 9, Milan, Italy Gatti Rita: Dipartimento di Scienze Biomediche, Biotecnologiche e Traslazionali, Unità di Anatomia, Istologia ed Embriologia, University of Parma, via Volturno 39, 43126, Parma, Italy Cabras Tiziana, Messana Irene: Dipartimento di Scienze della Vita e dell'Ambiente, University of Cagliari, Cittadella Universitaria, Monserrato, 09042, Cagliari, Italy Vitali Alberto: Istituto di Chimica per il Riconoscimento Molecolare, Italian National Research Council (CNR), Rome, L.go F. Vito,1 00168 Rome, Italy (literal)
Titolo
  • Structural and functional studies on a proline-rich peptide isolated from swine saliva endowed with antifungal activity towards Cryptococcus neoformans (literal)
Abstract
  • A proline-rich peptide of 2733Da, isolated from pig parotid granule preparations was tested against different pathogenic fungi. It showed interesting antifungal activity towards a clinical isolate of Cryptococcus neoformans, with an EC(50) of 2.2?M. Neither cytotoxic nor haemolytic effects were observed towards mammalian cells. Circular dichroism and infrared spectroscopic studies showed that the peptide adopted a combination of polyproline type-II, ?-turn and unordered conformations at physiological temperatures. Temperature dependent experiments evidenced a tendency to adopt a polyproline-II helix conformation. From experiments with lipid vesicles, Neutral Red Uptake (NRU), haemolytic assays, and confocal microscopy studies, it could be hypothesized that the peptide may exert its antifungal effect by interacting with an intracellular target rather than through membrane damage. (literal)
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