The relationship between electrospray ionization behavior and cytotoxic activity of [MI(P)4]+-type complexes (M = Cu, Ag and Au; P = tertiary phosphine) (Articolo in rivista)

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  • The relationship between electrospray ionization behavior and cytotoxic activity of [MI(P)4]+-type complexes (M = Cu, Ag and Au; P = tertiary phosphine) (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/rcm.6661 (literal)
Alternative label
  • Tisato F.; Crociani L.; Porchia M. ; Di Bernardo P.; Endrizzi F.; Santini C.; Seraglia R. (2013)
    The relationship between electrospray ionization behavior and cytotoxic activity of [MI(P)4]+-type complexes (M = Cu, Ag and Au; P = tertiary phosphine)
    in Rapid communications in mass spectrometry (Online); J. Wiley & sons, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tisato F.; Crociani L.; Porchia M. ; Di Bernardo P.; Endrizzi F.; Santini C.; Seraglia R. (literal)
Pagina inizio
  • 2019 (literal)
Pagina fine
  • 2027 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/doi/10.1002/rcm.6661/pdf (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 27 (literal)
Rivista
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  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1-3 : CNR Istituto di Chimica Inorganica e delle Superfici, Corso Stati Uniti 4, 35127 Padova, Italy / 4-5 : Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via Marzolo 1, 35131 Padova, Italy / 6 : Scuola di Scienze e Tecnologia, Divisione di Chimica, Università di Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy / 7 : CNR Istituto di Scienze e Tecnologie Molecolari, Corso Stati Uniti 4, 35127 Padova, Italy (literal)
Titolo
  • The relationship between electrospray ionization behavior and cytotoxic activity of [MI(P)4]+-type complexes (M = Cu, Ag and Au; P = tertiary phosphine) (literal)
Abstract
  • RATIONALE To try to find a correlation between the antiproliferative activity of a series of [MI(P)4]+ complexes (M = Cu, Ag and Au; P = tertiary phosphine) and their stability at micromolar concentration under mass spectrometric conditions. METHODS [M I(P)4]+ complexes were investigated by positive ion electrospray ionization mass spectrometry with multiple collisional experiments using an ion trap mass spectrometer. RESULTS The displacement of P from native [MI(P)4]+, previously described for the copper derivative, is common for the triad complexes leading to the formation of [M(P)3]+ and [M(P)2]+ adducts. Further dissociation of [M(P)2]+ depends on the nature of the metal (Cu ~ Ag > Au). More labile [Cu(P)2] + and [Ag(P)2]+ are more cytotoxic against HCT-15 human colon carcinoma cells compared to less labile [Au(P) 2]+ species. CONCLUSIONS The dissociation of P ligand(s) from the [MI(P)4]+ complexes is the driving force for the triggering of the antiproliferative activity. The more favored is the displacement of P from the [M(P)2]+ active form, the more favored is in turn the possibility for the metal to interact with biological substrates related to cancer proliferation. (literal)
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