WORDUP - AN EFFICIENT ALGORITHM FOR DISCOVERING STATISTICALLY SIGNIFICANT PATTERNS IN DNA-SEQUENCES Autori: (Articolo in rivista)

Type
Label
  • WORDUP - AN EFFICIENT ALGORITHM FOR DISCOVERING STATISTICALLY SIGNIFICANT PATTERNS IN DNA-SEQUENCES Autori: (Articolo in rivista) (literal)
Anno
  • 1992-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/nar/20.11.2871 (literal)
Alternative label
  • PESOLE, G; PRUNELLA, N.; LIUNI, S.; ATTIMONELLI, M.; SACCONE, C. (1992)
    WORDUP - AN EFFICIENT ALGORITHM FOR DISCOVERING STATISTICALLY SIGNIFICANT PATTERNS IN DNA-SEQUENCES Autori:
    in Nucleic acids research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • PESOLE, G; PRUNELLA, N.; LIUNI, S.; ATTIMONELLI, M.; SACCONE, C. (literal)
Pagina inizio
  • 2871 (literal)
Pagina fine
  • 2875 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 20 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 11 (literal)
Note
  • SCImago (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biochimica e Biologia Molecolare, Università di Bari Centro Studi sui Mitocondri e Metabolismo Energetico, CNR Bari (literal)
Titolo
  • WORDUP - AN EFFICIENT ALGORITHM FOR DISCOVERING STATISTICALLY SIGNIFICANT PATTERNS IN DNA-SEQUENCES Autori: (literal)
Abstract
  • We present here a fast and sensitive method designed to isolate short nucleotide sequences which have non-random statistical properties and may thus be biologically active. It is based on a first order Markov analysis and allows us to detect statistically significant sequence motifs from six to ten nucleotides long which are significantly shared (or avoided) in the sequences under investigation. This method has been tested on a set of 521 sequences extracted from the Eukaryotic Promoter Database (2). Our results demonstrate the accuracy and the efficiency of the method in that the sequence motifs which are known to act as eukaryotic promoters, such as the TATA-box and the CAAT-box, were clearly identified. In addition we have found other statistically significant motifs, the biological roles of which are yet to be clarified. (literal)
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