Characterization of female breast lesions from multi-wavelength time-resolved optical mammography (Articolo in rivista)

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Label
  • Characterization of female breast lesions from multi-wavelength time-resolved optical mammography (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1088/0031-9155/50/11/004 (literal)
Alternative label
  • L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. Danesini R. Cubeddu (2005)
    Characterization of female breast lesions from multi-wavelength time-resolved optical mammography
    in Physics in medicine and biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • L. Spinelli, A. Torricelli, A. Pifferi, P. Taroni, G. Danesini R. Cubeddu (literal)
Pagina inizio
  • 2489 (literal)
Pagina fine
  • 2502 (literal)
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  • 50 (literal)
Rivista
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  • 14 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Lorenzo Spinelli1, Alessandro Torricelli1, Antonio Pifferi1, Paola Taroni1, Gianmaria Danesini2 and Rinaldo Cubeddu1 1 INFM-Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy 2 Dipartimento di Radiologia, Casa di Cura S. Pio X, via Francesco Nava 31, I-20159 Milan, Italy (literal)
Titolo
  • Characterization of female breast lesions from multi-wavelength time-resolved optical mammography (literal)
Abstract
  • Characterization of both malignant and benign lesions in the female breast is presented as the result of a clinical study that involved more than 190 subjects in the framework of the OPTIMAMM European project. All the subjects underwent optical mammography, by means of a multi-wavelength time-resolved mammograph, in the range 637–985 nm. Optical images were processed by applying a perturbation model, relying on a nonlinear approximation of time-resolved transmittance curves in the presence of an inclusion, with the aim of estimating the major tissue constituents (i.e. oxyand deoxy-haemoglobin, lipid and water) and structural parameters (linked to dimension and density of the scatterer centres) for both the lesion area and the surrounding tissue. The critical factors for the application of the perturbation model on in vivo data are also discussed. Forty-six malignant and 68 benign lesions were analysed. A subset of 32 cancers, 40 cysts and 14 fibroadenomas were found reliable for the perturbation analysis. For cancers, we show a higher blood content with respect to the surrounding tissue, while cysts are characterized by a lower concentration of scattering centres with respect to the surrounding tissue. For fibroadenomas, the low number of cases does not allow any definite conclusions. doi:10.1088/0031-9155/50/11/004 (literal)
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