Structure elucidation of two diphenylhydantoin derivatives via 1H and 13C NMR spectroscopy (Articolo in rivista)

Type
Label
  • Structure elucidation of two diphenylhydantoin derivatives via 1H and 13C NMR spectroscopy (Articolo in rivista) (literal)
Anno
  • 1995-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/mrc.1260330716 (literal)
Alternative label
  • M. Ciechanowicz-Rutkowska, L. Ragona, F. Greco, L. Zetta, M. Pegna (1995)
    Structure elucidation of two diphenylhydantoin derivatives via 1H and 13C NMR spectroscopy
    in Magnetic resonance in chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • M. Ciechanowicz-Rutkowska, L. Ragona, F. Greco, L. Zetta, M. Pegna (literal)
Pagina inizio
  • 586 (literal)
Pagina fine
  • 591 (literal)
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  • 33 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • M. Ciechanowicz-Rutkowska, Regional Laboratory of Physicochemical Analysis and Structural Research, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland L. Ragona, F. Greco, L. Zetta: Istituto di Chimica delle Macromolecole, Laboratorio NMR, CNR, Milan, Italy M. Pegna: Italfarmaco, c/o Istituto di Chimica delle Macromolecole, Laboratorio NMR, CNR, Milan, Italy (literal)
Titolo
  • Structure elucidation of two diphenylhydantoin derivatives via 1H and 13C NMR spectroscopy (literal)
Abstract
  • The solution conformations of 1-benzyl-5,5-diphenyl-2,4-dioxo-3-imidazolidineacetic acid (AC) and 3-(2,4-dichlorobenzyl)-5,5-diphenyl-2,4-dioxo-1-imidazolidine acetic acid (AD) were studied by proton and carbon NMR spectroscopy. The two drugs have different pharmacological activities, AC having anticonvulsant and AD having antidepressant but no anticonvulsant properties. The relative orientations of the hydantoin ring substituents were investigated and are discussed in terms of amphipathic distribution of polar and apolar domains. (literal)
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