Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: a cross-sectional study (Articolo in rivista)

Type
Label
  • Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: a cross-sectional study (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3275/9064 (literal)
Alternative label
  • Claudio L. Lafortuna 1; Federica Prinelli 2,5; Fulvio Adorni 2; Fiorenza Agosti 3; Alessandra De Col 3; Alessandro Sartorio 3,4. (2013)
    Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: a cross-sectional study
    in Journal of endocrinological investigation (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Claudio L. Lafortuna 1; Federica Prinelli 2,5; Fulvio Adorni 2; Fiorenza Agosti 3; Alessandra De Col 3; Alessandro Sartorio 3,4. (literal)
Pagina inizio
  • 1062 (literal)
Pagina fine
  • 1068 (literal)
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  • Pubblicato on-line: 23 Luglio 2013 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 36 (literal)
Rivista
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  • 11 (literal)
Note
  • PubMe (literal)
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  • 1. Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Segrate (MI), Italy. 2. Istituto di Tecnologie Biomediche, Consiglio Nazionale delle Ricerche, Segrate (MI), Italy. 3. Istituto Auxologico Italiano, IRCCS, Laboratorio Sperimentale di Ricerche Auxoendocrinologiche and 4. III Divisione di Malattie Metaboliche, Milano and Piancavallo (VB) Italy. 5. Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, Italy. (literal)
Titolo
  • Effect of mechanical and metabolic factors on motor function and fatigue in obese men and women: a cross-sectional study (literal)
Abstract
  • Background - Mechanical overload and poor quality of contractile elements related to metabolic abnormalities concur to motor disability of obesity. The independent contribution of these factors to motor dysfunction in obese individuals is scarcely defined. Aim - Goal of the study is to test the hypothesis that metabolic factors may independently affect motor function in obesity. Methods - Leg maximum power output per unit body mass (W Mb), per unit fat-free mas (W FFM) and fatigue in daily functioning were assessed in 635 obese (BMI>=35 kg/m2) individuals (286 men, 349 women) aged 19-78 yr. The independent effects of age, BMI, insulin resistance and the five components of the metabolic syndrome on W Mb, W FFM and fatigue were evaluated by multivariate analysis. Results - A multiple regression analysis revealed that in both genders W Mb (denoting the individual's performance capability during anaerobic tasks) was independently reduced by age (p<0.001), BMI (p<0.05-0.001) and abnormalities of glucose metabolism (p<0.06- 0.01), while W FFM (representing the muscle intrinsic anaerobic capability) was affected only by age (p<0.001) and glucose metabolism impairment (p<0.06-0.01). In both genders fatigue was increased by age (p<0.001) and BMI (p<0.05-0.01), but augmented by low levels of HDL-cholesterol in men only (p<0.05). Conclusions - Beside the dependence from mechanical overload and age, low muscle power output in obese individuals was independently associated also with metabolic abnormalities related to impaired glucose homeostasis. Fatigue and performance, although similarly influenced by age and body mass excess, are affected by different metabolic factors. (literal)
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