http://www.cnr.it/ontology/cnr/individuo/prodotto/ID24385

Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1038/ijo.2009.254 (literal)

Alternative label

Kashyap S R; Daud S; Kelly K R; Gastaldelli Amalia; Win H; Brethauer S; Kirwan JP; Schauer PR (2010)
Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes
in International journal of obesity; NATURE PUBLISHING GROUP,, LONDON (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Kashyap S R; Daud S; Kelly K R; Gastaldelli Amalia; Win H; Brethauer S; Kirwan JP; Schauer PR (literal)

Pagina inizio

462 (literal)

Pagina fine

471 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

Epub 2009 Dec 22. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/20029383 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

34 (literal)

Rivista

International journal of obesity (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Cleveland Clin Fdn, Endocrinol & Metab Inst, Cleveland, OH 44195 USA 2. Cleveland Clin, Lerner Res Inst, Dept Pathobiol, Cleveland, OH 44106 USA 3. CNR, Fdn G Monasterio, Pisa, Italy 4. CNR, Inst Clin Physiol, Pisa, Italy 5. Cleveland Clin, Inst Digest Dis, Cleveland, OH 44106 USA (literal)

Titolo

Acute effects of gastric bypass versus gastric restrictive surgery on beta-cell function and insulinotropic hormones in severely obese patients with type 2 diabetes (literal)

Abstract

Context: Hyperglycemia resolves quickly after bariatric surgery, but the underlying mechanism and the most effective type of surgery remains unclear. Objective: To examine glucose metabolism and beta-cell function in patients with type 2 diabetes mellitus (T2DM) after two types of bariatric intervention; Roux-en-Y gastric bypass (RYGB) and gastric restrictive (GR) surgery. Design: Prospective, nonrandomized, repeated-measures, 4-week, longitudinal clinical trial. Patients: In all, 16 T2DM patients (9 males and 7 females, 52 +/- 14 years, 47 +/- 9 kg m(-2), HbA1c 7.2 +/- 1.1%) undergoing either RYGB (N = 9) or GR (N = 7) surgery. Outcome measures: Glucose, insulin secretion, insulin sensitivity at baseline, and 1 and 4 weeks post-surgery, using hyperglycemic clamps and C-peptide modeling kinetics; glucose, insulin secretion and gut-peptide responses to mixed meal tolerance test (MMTT) at baseline and 4 weeks post-surgery. Results: At 1 week post-surgery, both groups experienced a similar weight loss and reduction in fasting glucose (P<0.01). However, insulin sensitivity increased only after RYGB, (P<0.05). At 4 weeks post-surgery, weight loss remained similar for both groups, but fasting glucose was normalized only after RYGB (95 +/- 3mg 100 ml(-1)). Insulin sensitivity improved after RYGB (P<0.01) and did not change with GR, whereas the disposition index remained unchanged after RYGB and increased 30% after GR (P = 0.10). The MMTT elicited a robust increase in insulin secretion, glucagon-like peptide-1 (GLP-1) levels and beta-cell sensitivity to glucose only after RYGB (P<0.05). Conclusion: RYGB provides a more rapid improvement in glucose regulation compared with GR. This improvement is accompanied by enhanced insulin sensitivity and beta-cell responsiveness to glucose, in part because of an incretin effect. (literal)

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