Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cyto.2009.11.018 (literal)

Alternative label

• Del Ry S.; Giannessi D.; Maltinti M.; Cabiati M.; Prontera C.; Iervasi A.; Caselli C.; Mazzone A.; Neglia D. (2010)
  Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy.
  in Cytokine (Phila. Pa., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Del Ry S.; Giannessi D.; Maltinti M.; Cabiati M.; Prontera C.; Iervasi A.; Caselli C.; Mazzone A.; Neglia D. (literal)

Pagina inizio

• 325 (literal)

Pagina fine

• 330 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 49 (literal)

Rivista

• Cytokine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Cytokine, vol. 49 (3) pp. 325 - 330. elsevier, 2010. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, Scuola Superiore Sant'Anna, Pisa (Italy), Sector of Medicine, USL, Pisa (literal)

Titolo

• Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy. (literal)

Abstract

• In patients with dilated cardiomyopathy (DCM) abnormal myocardial blood flow (MBF) has been associated with coronary microvascular dysfunction. The aim of this study was to test the hypothesis that osteopontin (OPN) plasma levels could be associated with the activation of the renin-aldosterone system (RAS) in these patients and be involved in mediating myocardial and coronary damage. In 66 patients with idiopathic left ventricular dysfunction of variable severity the plasma levels of OPN were correlated with biomarkers of systemic metabolism, RAS activation, myocardial dysfunction and with clinical indexes of left ventricle (LV) function and perfusion obtained by 2D-echocardiography and PET. As compared to controls, patients showed a significant increase of inflammatory markers (OPN: 508+/-30.8ng/ml vs. 426.9+/-16.4, p0.05 and interleukin (IL)-6: 1.71+/-0.29pg/ml vs. 0.38+/-0.03pg/ml, p0.001) and of indexes of cardiac damage. OPN levels were significantly correlated with the extent of microvascular dysfunction (MBF at rest: p (literal)

Prodotto di

• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)

Autore CNR

• DANIELA GIANNESSI (Unità di personale interno)
• ANNALISA IERVASI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• DANIELA GIANNESSI (Unità di personale interno)
• SILVIA DEL RY (Unità di personale interno)
• ANNALISA IERVASI (Unità di personale interno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Meccanismi molecolari e biologici (ME.P05.018.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cytokine (Rivista)

Insieme di parole chiave di

• Keywords of "Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy." (Insieme di parole chiave)