http://www.cnr.it/ontology/cnr/individuo/prodotto/ID24329
Sulfido-peptide leukotrienes in coronary heart disease - relationship with disease instability and myocardial ischaemia. (Articolo in rivista)
- Type
- Label
- Sulfido-peptide leukotrienes in coronary heart disease - relationship with disease instability and myocardial ischaemia. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1365-2362.2010.02261.x (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- De Caterina R.; Giannessi D.; Lazzerini G.; Bernini W.; Sicari R.; Cupelli F.; Lenzi S.; Rugolotto M.; Madonna R.; Maclouf J. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- In: European Journal of Clinical Investigation, vol. 40 (3) pp. 258 - 272. Wiley, 2010. (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- *C.N.R. Institute of Clinical Physiology, Pisa, Italy,
+G. d'Annunzio University and Center of Excellence on Aging, Chieti, Italy,
?Ospedale di Treviso, Treviso, Italy,
§Hopital Lariboisiere, Paris, France (literal)
- Titolo
- Sulfido-peptide leukotrienes in coronary heart disease - relationship with disease instability and myocardial ischaemia. (literal)
- Abstract
- BACKGROUND: Urinary excretion of leukotriene (LT) E(4) is an index of LTC(4) biosynthesis and platelet-neutrophil interactions, which may occur in coronary heart disease and contribute to myocardial ischaemia. Enhanced LTC(4) biosynthesis may be a consequence of myocardial ischaemia or be linked to its pathogenetic substrate. METHODS AND RESULTS: Overnight urine collections were obtained from 17 patients with chronic stable angina, three patients with Prinzmetal's angina, 16 patients with non ST-elevation acute coronary syndromes (NSTE-ACS) and six patients with acute ST-elevation myocardial infarction (STEMI). LTE(4) excretion was measured by enzyme immunoassay after HPLC separation. Compared with healthy controls (51.1 +/- 21.3 pg mg(-1) creatinine, mean +/- SD, n = 11) and with non-coronary cardiac controls (36.6 +/- 9.8 pg mg(-1) creatinine, n = 9), LTE(4) excretion was unchanged in stable angina (40.5 +/- 25.8 pg mg(-1) creatinine), but significantly (P 0.01) increased in NSTE-ACS (122.7 +/- 137.2 pg mg(-1) creatinine) and STEMI (213.4 +/- 172.4 pg mg(-1) creatinine). In these patients, LTE(4) excretion rapidly dropped after day 1, consistent with effective coronary reperfusion. In patients with NSTE-ACS, the increase in LTE(4) excretion was entirely restricted to patients with recent ( 48 h) spontaneous anginal episodes. Myocardial ischaemia elicited by a positive exercise stress test was not accompanied by any detectable increase in LTE(4) excretion, while a significant (P 0.01) increase was detected after a single-vessel percutaneous coronary interventions (PCI) procedure (n (literal)
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