Mortality rate and outcome factors in mixed cryoglobulinaemia: the impact of hepatitis C virus (Articolo in rivista)

Type
Label
  • Mortality rate and outcome factors in mixed cryoglobulinaemia: the impact of hepatitis C virus (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3109/03009740903313639 (literal)
Alternative label
  • Della Rossa A; Tavoni A; D'Ascanio A; Catarsi E; Marchi F; Bencivelli W; Salvadori S; Migliorini P; Bombardieri S (2010)
    Mortality rate and outcome factors in mixed cryoglobulinaemia: the impact of hepatitis C virus
    in Scandinavian journal of rheumatology (Trykt. utg.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Della Rossa A; Tavoni A; D'Ascanio A; Catarsi E; Marchi F; Bencivelli W; Salvadori S; Migliorini P; Bombardieri S (literal)
Pagina inizio
  • 167 (literal)
Pagina fine
  • 170 (literal)
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  • 39 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Scandinavian Journal of Rheumatology, vol. 39 (2) pp. 167 - 170. Informa Healthcare, 2010. (literal)
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  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Internal Medicine, Rheumatology Unit, University of Pisa, Italy Department of Internal Medicine, Immunoallergology Unit, University of Pisa, Italy Istituto di Fisiologia Clinica - CNR, Pisa, Italy (literal)
Titolo
  • Mortality rate and outcome factors in mixed cryoglobulinaemia: the impact of hepatitis C virus (literal)
Abstract
  • Objectives: Mixed cryoglobulinaemia (MC) is a chronic small-vessel vasculitis. Shortly after the discovery of hepatitis C virus (HCV) in 1989, an association between HCV infection and MC was being increasingly reported, suggesting the potential pathogenetic implication of HCV in most of the cases that had been previously diagnosed as essential MC. A number of studies have pointed out prognostic factors linked to mortality in this disorder. None of them, however, have clarified the impact of HCV discovery on the natural history of the disease. The aim of the present study was to evaluate mortality in MC after the discovery of HCV infection. Methods: We retrospectively collected clinical and serological data in 70 unselected HCV-positive patients being followed up at our unit from 1990. Clinical and prognostic factors linked to poor outcome were evaluated. Results: Chronic hepatitis, renal involvement, and intestinal vasculitis were the most frequent causes of death. Conclusion: Compared to other series, the outcome in our MC seemed to be better. Factors linked to a poor outcome were renal involvement, widespread vasculitis, male sex, and cryocrit. (literal)
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