http://www.cnr.it/ontology/cnr/individuo/prodotto/ID24310

Case-Control Analysis of Paternal Age and Trisomic Anomalies. (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Case-Control Analysis of Paternal Age and Trisomic Anomalies. (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1136/adc.2009.176438 (literal)

Alternative label

K Morris J.; De Souza E.; Mosquera-Tenreiro C.; Francanett C.; Salvador J.; Portillo I.; Scarano G.; Calzolari E.; Stone D.; Verrelen-Dumoulin C.; Queisser-Luft A.; Gatt M.; Bakker M.; Garne E.; Khoshnood B.; Poetzsh S.; Bianca S.; Doray B.; Bianchi F.; Addor MC.; Tucker D.; Latos-Bielenska A.; Barisic I.; Dolk E.; Nelsen V.; (2010)
Case-Control Analysis of Paternal Age and Trisomic Anomalies.
in Archives of disease in childhood; BMJ Publishing Group (British Medical Journals), London (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

K Morris J.; De Souza E.; Mosquera-Tenreiro C.; Francanett C.; Salvador J.; Portillo I.; Scarano G.; Calzolari E.; Stone D.; Verrelen-Dumoulin C.; Queisser-Luft A.; Gatt M.; Bakker M.; Garne E.; Khoshnood B.; Poetzsh S.; Bianca S.; Doray B.; Bianchi F.; Addor MC.; Tucker D.; Latos-Bielenska A.; Barisic I.; Dolk E.; Nelsen V.; (literal)

Pagina inizio

893 (literal)

Pagina fine

897 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://adc.bmj.com/content/early/2010/06/28/adc.2009.176438.full.pdf (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

95 (literal)

Rivista

Archives of disease in childhood (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

In: Archives of Disease in Childhood, vol. 95 (11) pp. 893 - 897. BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health, 2010. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

11 (literal)

Note

ubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

E De Souza, J K Morris Joan K Morris, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Wolfson Institute of Preventive Medicine, London and EUROCAT Central Registry, Belfast: Helen Dolk Antwerp, Belgium: Vera Nelen Asturias, Spain: Carmen Mosquera-Tenreiro Auvergne, France: Christine Francannet Barcelona, Spain: Joaquin Salvador Basque Country, Spain: Isabel Portillo Campania, Italy: Gioacchino Scarano Emilia Romagna, Italy: Elisa Calzolari Glasgow, UK: David Stone Hainaut, Belgium: Christine Verellen-Dumoulin Mainz, Germany: Annette Queisser-Luft Malta: Miriam Gatt Netherlands: Marian Bakker Odense, Denmark: Ester Garne Paris, France: Babak Khoshnood Saxony-Anhalt, Germany: Simone Poetzsch Sicily, Italy (ISMAC): Sebastiano Bianca Strasbourg, France: Berenice Doray Tuscany, Italy: Fabrizio Bianchi Vaud, Switzerland: Marie-Claude Addor Wales, UK: David Tucker Wielkopolska, Poland: Anna Latos-Bielenska Zagreb, Croatia: Ingeborg Barisic (literal)

Titolo

Case-Control Analysis of Paternal Age and Trisomic Anomalies. (literal)

Abstract

Objectives To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome. Design Case-control: cases with each of these syndromes were matched to four controls with Down syndrome from within the same congenital anomaly register and with maternal age within 6 months. Setting Data from 22 EUROCAT congenital anomaly registers in 12 European countries. Participants Diagnoses with observed or (for terminations) predicted year of birth from 1980 to 2005, comprising live births, fetal deaths with gestational age >=20 weeks and terminations after prenatal diagnosis of the anomaly. Data include 374 cases of Patau syndrome, 929 of Edwards syndrome, 295 of Klinefelter syndrome, 28 of XYY syndrome and 5627 controls with Down syndrome. Main outcome measures Odds ratio (OR) associated with a 10-year increase in paternal age for each anomaly was estimated using conditional logistic regression. Results were adjusted to take account of the estimated association of paternal age with Down syndrome (1.11; 95% CI 1.01 to 1.23). Results The OR for Patau syndrome was 1.10 (95% CI 0.83 to 1.45); for Edwards syndrome, 1.15 (0.96 to 1.38); for Klinefelter syndrome, 1.35 (1.02 to 1.79); and for XYY syndrome, 1.99 (0.75 to 5.26). Conclusions There was a statistically signifi cant increase in the odds of Klinefelter syndrome with increasing paternal age. The larger positive associations of Klinefelter and XYY syndromes with paternal age compared with Patau and Edwards syndromes are consistent with the greater percentage of these sex chromosome anomalies being of paternal origin. (literal)

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