Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1136/hrt.2008.160309 (literal)

Alternative label

• Ait-Ali L, Andreassi MG, Foffa I, Spadoni I, Vano E, Picano E. (2009)
  Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease
  in Heart (Lond., 1996)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ait-Ali L, Andreassi MG, Foffa I, Spadoni I, Vano E, Picano E. (literal)

Pagina inizio

• 269 (literal)

Pagina fine

• 274 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://heart.bmj.com/content/early/2009/08/16/hrt.2008.160309 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 9 (literal)

Rivista

• Heart (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR Institute of Clinical Physiology, Pisa, Italy, G. Pasquinucci Hospital , G. Monasterio Foundation, Massa, Italy; Complutense University, Madrid, San Carlos University Hospital, Madrid, Spain (literal)

Titolo

• Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease (literal)

Abstract

• BACKGROUND: The seventh Committee on \"Biological effects of Ionizing Radiation\" (BEIR VII, 2006) underlines \"the need of studies of infants who are exposed to diagnostic radiation because catheters have been placed in their hearts\". OBJECTIVE: To determine the Lifetime Attributable Risk (LAR) of cancer associated with the estimated cumulative radiological dose in 59 children (42 males, age=2.8±3.2 years) with complex CHD, and to assess chromosomal DNA damage after cardiac catheterization procedures. METHODS: In all patients, the cumulative exposure was estimated as effective dose in milliSievert (mSv), and LAR cancer was determined from BEIR VII report. In a subset of 18 patients (13 males, age: 5 2± 5.7 years) micronucleus (MN) as biomarker of DNA damage and long-term risk predictor of cancer was assayed before and 2 hours after catheterization procedures. Dose-area product (DAP; Gy cm2) was assessed as measure of patient dose. RESULTS: The median life time cumulative effective dose was 7.7 mSv per patient (range 4.6- 41.2 mSv). Cardiac catheterization procedures and computed tomography were responsible for 95% of the total effective dose. For a 1-year-old child, the LAR cancer was 1 in 382 (25th-75th percentiles 1 in 531-1 in 187) and 1 in 156 (25th-75th percentiles 1 in 239-1 in 83) for male and female patients, respectively. Median MN values increased significantly after procedure when compared to baseline (pre= 6 ? vs post= 9 ?, p=0.02). The median of DAP values was 20 Gy cm2 (range of 1-277 Gy cm2). CONCLUSION: CHD children are exposed to a significant cumulative dose. Both indirect cancer risk estimations and direct DNA data emphasize the need for strict radiation dose optimization in children. (literal)

Prodotto di

• Epidemiologia clinica e molecolare (ME.P07.016.003) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• MARIAGRAZIA ANDREASSI (Unità di personale interno)
• LAMIA AIT ALI' (Unità di personale interno)
• EUGENIO PICANO (Persona)

Insieme di parole chiave

• Parole chiave di "Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIAGRAZIA ANDREASSI (Unità di personale interno)
• EUGENIO PICANO (Persona)
• LAMIA AIT ALI' (Unità di personale interno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Epidemiologia clinica e molecolare (ME.P07.016.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Heart (Rivista)

Insieme di parole chiave di

• Parole chiave di "Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease" (Insieme di parole chiave)