http://www.cnr.it/ontology/cnr/individuo/prodotto/ID242236

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. (Articolo in rivista) (literal)

Anno

1996-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1073/pnas.93.2.674 (literal)

Alternative label

Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM. (1996)
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.
in Proceedings of the National Academy of Sciences of the United States of America; NATIONAL ACADEMY OF SCIENCES, WASHINGTON (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM. (literal)

Pagina inizio

674 (literal)

Pagina fine

678 (literal)

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http://www.pnas.org/content/93/2/674.full.pdf (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

93 (literal)

Rivista

Proceedings of the National Academy of Sciences of the United States of America (Rivista)

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5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)
Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Institute of Genetics Biochemistry and Evolution, Consiglio Nazionale delle Ricerche, 27100, Pavia, Italy; Molecular Medicine Unit, Beth Israel Hospital, Boston, MA 02215; Department of Biological and Technological Research, San Raffaele Hospital, 20100, Milano,I taly; lnstitute for Cancer Research (IRCC), University of Torino Medical School, 10126, Torino, Italy. (literal)

Titolo

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. (literal)

Abstract

In hunting for unknown genes on the human X chromosome, we identified a cDNA in Xq28 encoding a transmembrane protein (SEX) of 1871 amino acids. SEX shares significant homology with the extracellular domain of the receptors encoded by the oncogenes MET, RON, and SEA [hepatocyte growth factor (HGF) receptor family]. Further screenings of cDNA libraries identified three additional sequences closely related to SEX: these were named SEP, OCT, and NOV and were located on human chromosomes 3p, 1, and 3q, respectively. The proteins encoded by these genes contain large cytoplasmic domains characterized by a distinctive highly conserved sequence (SEX domain). Northern blot analysis revealed different expression of the SEX family of genes in fetal tissues, with SEX, OCT, and NOV predominantly expressed in brain, and SEP expressed at highest levels in kidney. In situ hybridization analysis revealed that SEX has a distinctive pattern of expression in the developing nervous system of the mouse, where it is found in postmitotic neurons from the first stages of neuronal differentiation (9.5 day postcoitus). The SEX protein (220 kDa) is glycosylated and exposed at the cell surface. Unlike the receptors of the HGF family, p220SEX, a MET-SEX chimera or a constitutively dimerized TPR-SEX does not show tyrosine kinase activity. These data define a gene family (SEX family) involved in the development of neural and epithelial tissues, which encodes putative receptors with unexpected enzymatic or binding properties. (literal)

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