http://www.cnr.it/ontology/cnr/individuo/prodotto/ID242231
An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (Articolo in rivista)
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- An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (Articolo in rivista) (literal)
- Anno
- 1996-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1073/pnas.93.2.695 (literal)
- Alternative label
Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P. (1996)
An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
in Proceedings of the National Academy of Sciences of the United States of America; NATIONAL ACADEMY OF SCIENCES, WASHINGTON (Stati Uniti d'America)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P. (literal)
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- http://www.pnas.org/content/93/2/695.long (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Istituto di Genetica Biochimica ed Evoluzionistica, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy; Dipartimento di Medicina, University of Perugia, 06122 Perugia, Italy; European Institute of Oncology, Milan, 20141 Italy; Department of Biology, University of Roma Tor Vergata, 00144 Rome, Italy; Department of Experimental Medicine and Pathology,University of Roma La Sapienza, 00185 Rome, Italy. (literal)
- Titolo
- An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells. (literal)
- Abstract
- An increasingly large number of proteins involved in signal transduction have been identified in recent years and shown to control different steps of cell survival, proliferation, and differentiation. Among the genes recently identified at the tip of the long arm of the human X chromosome, a novel gene, C1, encodes a protein that appears to represent a newly discovered member of the group of signaling proteins involved in regulation of the small GTP binding proteins of the ras superfamily. The protein encoded by C1, p115, is synthesized predominantly in cells of hematopoietic origin. It is characterized by two regions of similarity to motifs present in known proteins: GAP and SH3 homologous regions. Its localization in a narrow cytoplasmic region just below the plasma membrane and its inhibitory effect on stress fiber organization indicate that p115 may down regulate rho-like GTPases in hematopoietic cells. (literal)
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