http://www.cnr.it/ontology/cnr/individuo/prodotto/ID24208

Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/hep.23031 (literal)

Alternative label

Vanni E, Abate ML, Gentilcore E, Hickman I, Gambino R, Cassader M, Smedile A, Ferrannini E, Rizzetto M, Marchesini G, Gastaldelli A, Bugianesi E. (2009)
Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C
in Hepatology (Baltim. Md.); Williams & Wilkins, Baltimore, MD (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Vanni E, Abate ML, Gentilcore E, Hickman I, Gambino R, Cassader M, Smedile A, Ferrannini E, Rizzetto M, Marchesini G, Gastaldelli A, Bugianesi E. (literal)

Pagina inizio

697 (literal)

Pagina fine

706 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.ncbi.nlm.nih.gov/pubmed/19582803 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

50 (literal)

Rivista

Hepatology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

[ 1,2,3,7,9,12 ] Univ Turin, Div Gastrohepatol, San Giovanni Battista Hosp, I-10126 Turin, Italy [ 5,6 ] Univ Turin, Dept Internal Med, San Giovanni Battista Hosp, I-10126 Turin, Italy [ 4 ] Univ Queensland, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld, Australia [ 8 ] Univ Pisa, Dept Internal Med, I-56100 Pisa, Italy [ 10 ] Univ Bologna, Bologna, Italy [ 11 ] CNR, Fdn G Monasterio, I-56100 Pisa, Italy [11 ] CNR, Inst Clin Physiol, I-56100 Pisa, Italy (literal)

Titolo

Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C (literal)

Abstract

Chronic hepatitis C (CHC) has been associated with type 2 diabetes and insulin resistance, but the extent of impairment in insulin action, the target pathways involved, and the role of the virus per se have not been defined. In this study, we performed a euglycemic hyperinsulinemic clamp (1 mU x minute(-1) x kg(-1)) coupled with infusion of tracers ([6,6-(2)H(2)]glucose, [(2)H(5)]glycerol) and indirect calorimetry in 14 patients with biopsy-proven CHC, who were selected not to have any features of the metabolic syndrome, and in seven healthy controls. We also measured liver expression of inflammatory cytokines/mediators and tested their association with the metabolic parameters. Compared to controls, in patients with CHC: (1) total glucose disposal (TGD) during the clamp was 25% lower (P = 0.003) due to impaired glucose oxidation (P = 0.0002), (2) basal endogenous glucose production (EGP) was 20% higher (P = 0.011) and its suppression during the clamp was markedly reduced (P = 0.007), and (3) glycerol appearance was not different in the basal state or during the clamp, but lipid oxidation was less suppressed by insulin (P = 0.004). Lipid oxidation was higher in patients with CHC who had more steatosis and was directly related to EGP, TGD, and glucose oxidation. The decreased insulin-stimulated suppression of EGP was associated with increased hepatic suppressor of cytokine signaling 3 (SOCS3; P < 0.05) and interleukin-18 (P < 0.05) expression. Conclusion: Hepatitis C infection per se is associated with peripheral and hepatic insulin resistance. Substrate competition by increased lipid oxidation and possibly enhanced hepatic expression of inflammatory cytokines/mediators could be involved in the defective glucose regulation. (literal)

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