http://www.cnr.it/ontology/cnr/individuo/prodotto/ID24104
Full experimental modelling of a liver tissue mimicking phantom for medical ultrasound studies employing different hydrogels (Articolo in rivista)
- Type
- Label
- Full experimental modelling of a liver tissue mimicking phantom for medical ultrasound studies employing different hydrogels (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s10856-008-3644-6 (literal)
- Alternative label
Casciaro S, Conversano F, Musio S, Casciaro E, Demitri C, Sannino A. (2009)
Full experimental modelling of a liver tissue mimicking phantom for medical ultrasound studies employing different hydrogels
in Journal of materials science. Materials in medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Casciaro S, Conversano F, Musio S, Casciaro E, Demitri C, Sannino A. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Institute of Clinical Physiology, National Council of Research (IFC-CNR); Bioengineering Division, Euro Mediterranean Scientific Biomedical Institute; Department of Engineering for Innovation, University of Salento. (literal)
- Titolo
- Full experimental modelling of a liver tissue mimicking phantom for medical ultrasound studies employing different hydrogels (literal)
- Abstract
- Tissue mimicking phantoms have been widely
reported to be an important tool for development, optimisation
and performance testing of ultrasound-based
diagnostic techniques. In particular, modern applications of
tissue mimicking phantoms often include characterisation of
the nonlinear behaviour of experimental ultrasound contrast
agents. In such cases, the tissue-mimicking materials should
be chosen not only based on the values of their density, speed
of sound and attenuation coefficient, but also considering
their effect on the appearance of ''native harmonics'' due to
nonlinear distortion of ultrasound signal during propagation.
In a previous paper it was demonstrated that a cellulosebased
hydrogel is suitable to simulate nonlinear acoustical
behaviour of liver tissue for thicknesses up to 8 cm. In this
paper we present the experimental characterisation of the
nonlinear acoustical behaviour of a different polyethylene
glycol diacrylate (PEGDA)-based hydrogel, in order to
assess whether and how it can improve the performances and
overcome some limitations of the cellulose-based hydrogel
as liver tissue-mimicking material. Samples of pig liver
tissue, cellulose-based hydrogel and PEGDA-based hydrogel
were insonified in a through-transmission set-up,
employing 2.25-MHz pulses with different mechanical
index (MI) values. Second harmonic and first harmonic
amplitudes were extracted from the spectra of received
signals and their difference was then used to compare
sample behaviours. Obtained results show how a new more
accurate and combined experimental model of linear and
nonlinear acoustical behaviour of liver tissue is feasible. In
fact, a further confirmation of the cellulose-based hydrogel
effectiveness to precisely simulate the liver tissue for penetration
depths up to 8 cm was provided, and it was also
shown that the employment of the PEGDA-based hydrogel
can extend the range of useful tissue-mimicking material
thicknesses up to 11 cm, moreover allowing a considerable
improvement of the time stability and behaviour reliability
of the corresponding manufactured phantoms. (literal)
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- Autore CNR
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